CHRONIC ADMINISTRATION OF IMIPRAMINE ANTAGONIZES DERANGED CIRCADIAN-RHYTHM PHASES IN INDIVIDUALLY HOUSED RATS
CHRONIC ADMINISTRATION OF IMIPRAMINE ANTAGONIZES DERANGED CIRCADIAN-RHYTHM PHASES IN INDIVIDUALLY HOUSED RATS
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DOI：
10.1016/0031-9384(90)90262-3
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发表时间：
1990-07-01
影响因子：
2.9
通讯作者：
DEFRANCISCIS, P
中科院分区：
文献类型：
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作者：
GRECO, AM;GAMBARDELLA, P;DEFRANCISCIS, P
测定雄性 Wistar 大鼠下丘脑血清素 (5HT)、色氨酸 (TP) 和 5-羟基吲哚乙酸 (5HIAA) 以及血清皮质酮的昼夜节律。这些动物经历了为期五周的12:12小时光/暗周期调理期，并被分为三组：将四只大鼠关在一个笼子里（C组，对照组），单独饲养的大鼠（I组），以及单独饲养的大鼠，并通过植入皮下的渗透泵连续给予10 mg/kg/天的丙咪嗪治疗两周（T组）。 I组和C组的5HT、TP和5HIAA末相有显着差异，I组皮质酮中枢高于C组。相反，T组（单独饲养，但给予丙咪嗪）和C组之间没有观察到差异。因此，长期施用丙咪嗪可以拮抗单独饲养引起的昼夜节律变化。
The circadian rhythms of hypothalamic serotonin (5HT), tryptophan (TP) and 5-hydroxy-indoleacetic acid (5HIAA), and serum corticosterone were determined in male Wistar rats. The animals underwent a five-week 12:12-hr light/dark cycle conditioning period and were divided into three groups: rats housed four to a cage (group C, control), rats housed individually (group I), and rats housed individually and treated for two weeks with 10 mg/kg/day of imipramine continuously administered by osmotic pumps implanted under the skin (group T). Significant differences were found in the acrophases of 5HT, TP and 5HIAA between group I and group C, and corticosterone mesor was higher in group I than in group C. On the contrary, no differences were observed between group T (individually housed, but given imipramine) and group C. Therefore, chronically administered imipramine antagonizes the circadian changes induced by individual housing.