Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.
Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.
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诱导型一氧化氮合酶（INOS）表达可能预测人黑色素瘤中的远处转移。
DOI：
10.1038/sj.bjc.6690256
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发表时间：
1999-03
影响因子：
8.8
通讯作者：
Pehamberger, H
中科院分区：
文献类型：
--
作者：
Tschugguel, W;Pustelnik, T;Lass, H;Mildner, M;Weninger, W;Schneeberger, C;Jansen, B;Tschachler, E;Waldhor, T;Huber, J C;Pehamberger, H
研究了诱导型一氧化氮合酶（iNOS）在人黑色素瘤皮下或淋巴结转移中的表达及其细胞定位。免疫组化显示iNOS的表达仅限于黑色素瘤细胞。在无远处转移的患者样本中，iNOS+肿瘤细胞数/总肿瘤细胞数为55%±17% (n = 12)，而在3年观察期内发生肺、肝或脑远处转移的患者样本中，iNOS+肿瘤细胞数/总肿瘤细胞数为9%±8% (n = 10) （P < 0.001）。Western blotting证实部分病例有iNOS蛋白表达。值得注意的是，iNOS在区域黑色素瘤转移中表达，其表达与肿瘤的转移潜力呈负相关。因此，iNOS表达可能对人类黑色素瘤远处转移的发展具有预测价值。©1999癌症研究运动
Expression of inducible nitric oxide synthase (iNOS) and its cellular localization was investigated in subcutaneous or lymph node metastases of human melanoma. Immunohistochemistry revealed that iNOS expression was limited to melanoma cells. In samples of patients without distant metastases, the number of iNOS+ tumour cells/total tumour cells was 55% ± 17% (n = 12) compared with 9% ± 8% when distant metastases of lung, liver or brain occurred within an observation period of 3 years (n = 10) (P < 0.001). Western blotting confirmed the expression of iNOS protein in select cases. Notably, iNOS is expressed in regional melanoma metastases and its expression is inversely related to the tumour's metastatic potential. Thus, iNOS expression may have predictive value for the development of distant metastases of human melanoma. © 1999 Cancer Research Campaign