PROSTATIC INDUCTION - INTERACTION OF EPITHELIUM AND MESENCHYME FROM NORMAL WILD-TYPE MICE AND ANDROGEN-INSENSITIVE MICE WITH TESTICULAR FEMINIZATION
PROSTATIC INDUCTION - INTERACTION OF EPITHELIUM AND MESENCHYME FROM NORMAL WILD-TYPE MICE AND ANDROGEN-INSENSITIVE MICE WITH TESTICULAR FEMINIZATION
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DOI：
10.1677/joe.0.0850423
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发表时间：
1980-01-01
影响因子：
4
通讯作者：
MIZUNO, T
中科院分区：
文献类型：
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作者：
LASNITZKI, I;MIZUNO, T
前列腺由尿生殖窦发育而来，上皮芽伸入周围的间质。使用正常和雄激素不敏感的Tfm小鼠（雄激素受体缺乏）的窦确定间充质在此过程中的作用。将两种类型窦的上皮和间充质分离并重组，重组体在睾酮存在下的器官培养中生长。由正常上皮和正常间充质组成的重组体形成了上皮芽，突起到周围的间充质中，但在突变小鼠的上皮和间充质的重组体中没有芽形成。在正常间充质的突变小鼠的上皮细胞的重组体中，上皮细胞发育的前列腺芽和数量相似，如果正常上皮细胞与正常间充质。正常上皮与突变小鼠间质结合不能形成前列腺芽。间充质明显决定前列腺芽的发育，突变体间充质缺乏诱导能力可能是由于间充质雄激素受体缺乏。
The prostate gland develops from the urogenital sinus as epithelial buds projecting into the surrounding mesenchyme. The role of the mesenchyme in this process was determined using sinuses from normal and androgen-insensitive Tfm mice which are deficient in androgen receptors. Epithelium and mesenchyme from botht types of sinus were separated and recombined and the recombinants grown in organ culture in the presence of testosterone. Recombinants consisting of normal epithelium and normal mesenchyme developed epithelial buds projecting into the surrounding mesenchyme but no buds were formed in recombinants of epithelium and mesenchyme from mutant mice. In recombinants of epithelium from mutant mice with normal mesenchyme the epithelium developed prostatic buds and the number was similar to that found if normal epithelium was associated with normal mesenchyme. Normal epithelium combined with mesenchyme from mutant mice failed to form prostatic buds. The mesenchyme apparently determines the development of prostatic buds and the lack of inductive capacity of the mesenchyme from mutant may be due to a deficiency of mesenchymal androgen receptors.