Does basal production of nitric oxide contribute to regulation of brain-fluid balance?
Does basal production of nitric oxide contribute to regulation of brain-fluid balance?
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一氧化氮的基础产生是否有助于调节脑液平衡？
DOI：
10.1152/ajpheart.1992.262.2.h340
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Heistad,DD
中科院分区：
文献类型：
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作者：
Faraci,FM;Heistad,DD
一氧化氮（NO）或含NO的化合物似乎介导内皮依赖性舒张，并可能影响静息血管张力。本研究的目的是检验一氧化氮的形成对脑和脉络丛的血流有重要影响的假设。我们用微球测量了麻醉家兔的血流量。静脉注射NG-硝基-L-精氨酸（L-NNA，3和30 mg/kg），一种精氨酸类似物，抑制NO的酶促形成，对脑血流量没有显着影响。注射L-NNA后动脉压维持在对照水平。相比之下，L-NNA使脉络丛的血流量从对照值563 +/- 77 ml.min-1. 100 g-1分别降低了36 +/- 4（平均值+/- SE）和51 +/- 8%（两种剂量的P均小于0.05）。L-NNA也减少了流向肾脏的血流量，但其作用往往小于在脉络丛中观察到的作用。脉络丛和肾脏的血流量减少受到L-精氨酸（60 mg.kg-1.min-1）预处理的抑制。单独使用L-精氨酸对脉络丛、大脑或肾脏的血流几乎没有影响。这些研究结果表明，NO，或一个密切相关的化合物，来自L-精氨酸有重要影响的基础灌注脉络丛，形成脑脊液的主要网站。
Nitric oxide (NO), or a NO-containing compound, appears to mediate endothelium-dependent relaxation and may influence resting vascular tone. The goal of the present study was to examine the hypothesis that formation of NO has an important influence on blood flow to the brain and the choroid plexus. We measured blood flow with microspheres in anesthetized rabbits. Intravenous injection of NG-nitro-L-arginine (L-NNA, 3 and 30 mg/kg), an analogue of arginine that inhibits the enzymatic formation of NO, had no significant effect on cerebral blood flow. Arterial pressure was maintained at control levels after injection of L-NNA. In contrast, L-NNA decreased blood flow to the choroid plexus by 36 +/- 4 (mean +/- SE) and 51 +/- 8% (P less than 0.05 for both doses), respectively, from a control value of 563 +/- 77 ml.min-1.100 g-1. L-NNA also reduced blood flow to the kidney, but the effect tended to be less than that observed in the choroid plexus. Decreases in blood flow to the choroid plexus and kidney were inhibited by pretreatment with L-arginine (60 mg.kg-1.min-1). L-Arginine alone had little effect on blood flow to the choroid plexus, brain, or kidney. These findings suggest that NO, or a closely related compound, derived from L-arginine has important effects on basal perfusion of the choroid plexus, the major site of formation of cerebrospinal fluid.