Is the effect of tinnitus on auditory steady-state response amplitude mediated by attention?
Is the effect of tinnitus on auditory steady-state response amplitude mediated by attention?
复制标题
耳鸣对听觉稳态反应幅度的影响是由注意力介导的吗？
DOI：
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发表时间：
2012
影响因子：
3
通讯作者：
A. Rupp
中科院分区：
文献类型：
--
作者：
E. Diesch;M. Andermann;A. Rupp
目的：耳鸣患者的听觉稳态反应（ASSR）振幅增强效应已被报道。由于注意也能增强ASSR的振幅，耳鸣对ASSR振幅的影响可以解释为耳鸣介导的注意效应。由于N1的注意效应明显大于ASSR，如果耳鸣对ASSR振幅的影响是由于注意，那么耳鸣对听觉诱发反应的N1分量的振幅增强效应应该是相似的。方法：MEG记录，其先前被检查用于ASSR（Diesch等人，2010a）相对于N1m分量进行了分析。与以前的ASSR一样，N1m在源域（源空间投影）中进行分析。刺激是调幅（AM）音调，其中三个载波频率之一匹配耳鸣频率或替代频率高于听力边缘频率1½倍频程（对照组），听力边缘频率和低于听力边缘的频率。在单一条件下呈现单个AM音，在复合条件下呈现载波和调制频率不同的三个AM音的叠加。结果：在早期的ASSR研究中（Diesch等人，2010a），耳鸣患者的ASSR振幅，而不是在对照组中，在（替代）耳鸣条件下比在边缘条件下显著更大。在复合条件下，患者的ASSR反应的相互抑制证据少于对照组。在本研究中，N1m的振幅引起的刺激位于听力边缘和（替代）耳鸣频率小于N1m的振幅引起的亚边缘音在患者和对照组。在复合条件下的N1m响应的N1m响应在单一条件下的关系表明，相互抑制组件N1m响应之间的患者与对照组相比减少。结论：在本研究中，没有证据表明耳鸣的N1振幅增强效应。与对照组相比，耳鸣患者的相互抑制减少。因此，由于注意力对N1m没有潜在的影响，耳鸣对ASSR振幅的增强作用似乎不太可能通过耳鸣引起的注意力来解释。
Objectives: Auditory steady-state response (ASSR) amplitude enhancement effects have been reported in tinnitus patients. As ASSR amplitude is also enhanced by attention, the effect of tinnitus on ASSR amplitude could be interpreted as an effect of attention mediated by tinnitus. As N1 attention effects are significantly larger than those on the ASSR, if the effect of tinnitus on ASSR amplitude were due to attention, there should be similar amplitude enhancement effects in tinnitus for the N1 component of the auditory-evoked response. Methods: MEG recordings which were previously examined for the ASSR (Diesch et al., 2010a) were analyzed with respect to the N1m component. Like the ASSR previously, the N1m was analyzed in the source domain (source space projection). Stimuli were amplitude-modulated (AM) tones with one of three carrier frequencies matching the tinnitus frequency or a surrogate frequency 1½ octave above the audiometric edge frequency in controls, the audiometric edge frequency, and a frequency below the audiometric edge. Single AM-tones were presented in a single condition and superpositions of three AM-tones differing in carrier and modulation frequency in a composite condition. Results: In the earlier ASSR study (Diesch et al., 2010a), the ASSR amplitude in tinnitus patients, but not in controls, was significantly larger in the (surrogate) tinnitus condition than in the edge condition. Patients showed less evidence than controls of reciprocal inhibition of component ASSR responses in the composite condition. In the present study, N1m amplitudes elicited by stimuli located at the audiometric edge and at the (surrogate) tinnitus frequency were smaller than N1m amplitudes elicited by sub-edge tones both in patients and controls. The relationship of the N1m response in the composite condition to the N1m response in the single condition indicated that reciprocal inhibition among component N1m responses was reduced in patients compared against controls. Conclusions: In the present study, no evidence was found for an N1-amplitude enhancement effect in tinnitus. Compared to controls, reciprocal inhibition is reduced in tinnitus patients. Thus, as there is no effect on N1m that could potentially be attributed to attention, it seems unlikely that the enhancement effect of tinnitus on ASSR amplitude could be accounted for in terms of attention induced by tinnitus.
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影响因子：
2.5
作者：
Kaur, S;Lazar, R;Metherate, R
通讯作者：
Metherate, R
影响因子：
2.5
作者：
RHODE, WS;GREENBERG, S
通讯作者：
GREENBERG, S
DOI：
10.1098/rstb.1998.0281
发表时间：
1998-08-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Hillyard, SA;Vogel, EK;Luck, SJ
通讯作者：
Luck, SJ
影响因子：
2.5
作者：
Gu, Jianwen Wendy;Halpin, Christopher F.;Melcher, Jennifer R.
通讯作者：
Melcher, Jennifer R.
初级听觉皮层的言语诱发活动：发声时间的影响。
DOI：
10.1016/0168-5597(94)90005-1
发表时间：
1994
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Steinschneider,M;Schroeder,CE;Arezzo,JC;VaughanJr,HG
通讯作者：
VaughanJr,HG