NUCLEAR-MAGNETIC-RESONANCE IMAGING OF A SINGLE CELL
NUCLEAR-MAGNETIC-RESONANCE IMAGING OF A SINGLE CELL
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DOI：
10.1038/322190a0
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发表时间：
1986-07-10
期刊：
影响因子：
64.8
通讯作者：
HINTERMANN, M
中科院分区：
文献类型：
--
作者：
AGUAYO, JB;BLACKBAND, SJ;HINTERMANN, M
核磁共振 (NMR) 成像1,2现已成为临床成像领域的成熟工具，与传统的 X 射线计算机断层扫描 (CT) 扫描 3 具有良好的竞争优势。 NMR 成像背后的驱动力主要集中在全身成像领域，该领域在临床上仅限于高达 1.5 T (60 MHz) 的领域。人们认识到，获得亚毫米空间分辨率的图像可能具有巨大的优势4,5。此外，在较高磁场下成像可能会有好处，因为信号随着磁场的平方而增加6。使用改进的 9.5 T 89 毫米孔径高分辨率核磁共振波谱仪，我们现在获得了第一张单细胞核磁共振图像，证明了核磁共振成像显微镜的出现。核磁共振显微镜预计将在生物学、医学和材料科学领域产生相当大的影响，并可能成为在人类受试者上获得此类分辨率的先驱。
Nuclear magnetic resonance (NMR) imaging1,2is now an established tool in clinical imaging and competes favourably with conventional X-ray computerized tomography (CT) scanning3. The drive behind NMR imaging has primarily been in the area of whole-body imaging, which has been limited clinically to fields of up to 1.5 T (60 MHz). It is recognized that there may be substantial advantages in obtaining images with sub-millimetre spatial resolution4,5. Also, there may be benefits to imaging at higher fields, since the signal increases as the square of the magnetic field6. Using a modified 9.5 T 89-mm-bore high-resolution NMR spectrometer, we have now obtained the first NMR images of a single cell, demonstrating the advent of the NMR imaging microscope. The NMR microscope is expected to have considerable impact in the areas of biology, medicine and materials science, and may serve as a precursor to obtaining such resolutions on human subjects.