The spectrum of thyroid disorders in an iodine-deficient community: The Pescopagano survey
The spectrum of thyroid disorders in an iodine-deficient community: The Pescopagano survey
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DOI：
10.1210/jc.84.2.561
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发表时间：
1999-02-01
影响因子：
5.8
通讯作者：
Pinchera, A
中科院分区：
文献类型：
--
作者：
Aghini-Lombardi, F;Antonangeli, L;Pinchera, A
我们通过超声波仔细评估了1411名受试者的甲状腺状况和甲状腺肿大，这些受试者几乎代表了意大利南部缺碘村Pescopagano的全部常住人口。尿碘排泄量中位数为55 μ g/L。儿童甲状腺肿患病率为16.0%，成人患病率为59.8%。甲状腺结节在儿童中为0.5%，随着年龄的增长逐渐增加，在56- 65岁组中达到28.5%。目前或既往甲状腺功能亢进的患病率为2.9%，其中中毒性弥漫性甲状腺肿9例，中毒性结节性甲状腺肿20例。功能自主在儿童中很少见，随着年龄的增长逐渐增加，在老年人中达到15.4%，并且与结节性甲状腺肿有关。成人明显和亚临床甲状腺功能减退的患病率分别为0.2%和3.8%。12.6%的人血清中检测到甲状腺球蛋白和甲状腺过氧化物酶自身抗体。弥漫性自身免疫性甲状腺炎的患病率为3.5%，在儿童中非常低。甲状腺癌仅1例。总之，在目前对缺碘社区的调查中，观察到甲状腺肿患病率、甲状腺结节性和功能自主性随着年龄的增长而逐渐增加。甲状腺机能亢进是碘充足地区报告的两倍，主要是由于中毒性结节性甲状腺肿的频率增加。虽然低效价血清甲状腺抗体相对频繁，但显性和亚临床自身免疫性甲状腺功能减退的患病率与碘充足地区的患病率没有什么不同。
We carefully assessed thyroid status and goiter by ultrasound in 1411 subjects virtually representing the entire resident population of Pescopagano, an iodine-deficient village of Southern Italy. Median urinary iodine excretion was 55 mu g/L. The prevalence of goiter was 16.0% in children and 59.8% in adults. Thyroid nodularity was 0.5% in children and progressively increased with age to 28.5% in the 56-to 65-yr-old group. The prevalence of present or past hyperthyroidism was 2.9%, including 9 cases with toxic diffuse goiter and 20 with toxic nodular goiter. Functional autonomy was rare in children, progressively increased with age up to 15.4% in the elderly, and was related to nodular goiter. The prevalences of overt and subclinical hypothyroidism in the adults were 0.2% and 3.8%, respectively. Serum autoantibodies to thyroglobulin and thyroperoxidase were detected in 12.6% of the entire population. The prevalence of diffuse autoimmune thyroiditis was 3.5%, being very low in children. Thyroid cancer was found in only 1 case. In conclusion, in the present survey of an iodine-deficient community, a progressive increase with age of goiter prevalence, thyroid nodularity, and functional autonomy was observed. Hyperthyroidism was twice as high as that reported in iodine-sufficient areas, mainly due to an increased frequency of toxic nodular goiter. Although low titer serum thyroid antibodies were relatively frequent,, the prevalences of both overt and subclinical autoimmune hypothyroidism were not different from those observed in iodine-sufficient areas.