Localization of basement membrane components in mucous membrane pemphigoid.
Localization of basement membrane components in mucous membrane pemphigoid.
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粘膜类天疱疮基底膜成分的定位。
DOI：
10.1111/1523-1747.ep12275033
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Greenspan,JS
中科院分区：
文献类型：
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作者：
Meyer,JR;Migliorati,CA;Daniels,TE;Greenspan,JS
我们检查了层粘连蛋白、IV型胶原和纤连蛋白在口腔粘膜类天疱疮（MMP）上皮下囊泡中的分布。这些大分子的间接免疫荧光染色进行了10个冷冻活检标本的口腔MMP。我们发现IV型胶原蛋白的结缔组织地板和层粘连蛋白的上皮屋顶这些病变。我们的研究结果表明，口腔MMP的炎症损伤可能会破坏层粘连蛋白与IV型胶原在基底膜区的相互作用。
We examined the distribution of laminin, type IV collagen, and fibronectin in subepithelial vesicles of oral mucous membrane pemphigoid (MMP). Indirect immunofluorescence staining of these macromolecules was performed on 10 frozen biopsy specimens of oral MMP. We found type IV collagen in the connective tissue floor and laminin in the epithelial roof of these lesions. Our results suggest that the inflammatory injury in oral MMP may disrupt the interaction of laminin with type IV collagen in the basement membrane zone.