Linear energy transfer weighted beam orientation optimization for intensity-modulated proton therapy.
Linear energy transfer weighted beam orientation optimization for intensity-modulated proton therapy.
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DOI：
10.1002/mp.14329
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发表时间：
2021-01
期刊：
影响因子：
3.8
通讯作者：
Sheng K
中科院分区：
文献类型：
--
作者：
Gu W;Ruan D;Zou W;Dong L;Sheng K
在IMPT中，生物学有效性的无关差异有助于恒定的相对生物学有效性（RBE）模型的预测和实验性观察。
这使得加权的BOO（LETWBOO）框架使用剂量（让×D）作为生物学替代品。从600–800起非旋转候选梁在2到4之间。这种LETWBOO方法在三个头骨碱肿瘤（SBT）患者和三名双边头颈（H＆N）患者上进行了测试。
LETWBOO计划平均显示出较高的物理剂量，而letwboo中的桨中的[2.85，4.6] gyrbe在SBT案例中的降低，并减少了[0.9，2.5] gyrbe在H＆n案件中，而Letwman则与Man clet with s clob with to Letw s clet with scem and perw and per per pet;因子为0.04μm/keV。平均而言，在SBT案例中，Letwboo从[1.1，2.9] Gy降低了oar [平均值，最大] clet×d，而不是[0.7，1.7] gy的莱特曼（Letwman）在h＆n情况下的降低。 0.3，1.2] gy。
我们开发了一种新颖的让加权BOO方法用于IMPT，与BOO的生物学效应没有说明的计划相比，具有改进的物理和生物桨横幅的生成计划。
In IMPT, unaccounted-for variation in biological effectiveness contributes to the discrepancy between the constant relative biological effectiveness (RBE) model prediction and experimental observation. It is desirable to incorporate biological doses in treatment planning to improve modeling accuracy and consequently achieve a higher therapeutic ratio. This study addresses this demand by developing a method to incorporate linear energy transfer (LET) into beam orientation optimization (BOO). Instead of RBE-weighted dose, this LET weighted BOO (LETwBOO) framework uses the dose and LET product (LET×D) as the biological surrogate. The problem is formulated with a physical dose fidelity term, a LET×D constraint term, and a group sparsity term. The LET×D of OARs are penalized for minimizing the biological effect while maintaining the physical dose objectives. Group sparsity is used to reduce the number of active beams from 600–800 non-coplanar candidate beams to between 2 and 4. This LETwBOO method was tested on three skull-base tumor (SBT) patients and three bilateral head-and-neck (H&N) patients. The LETwBOO plans were compared with IMPT plans using manually selected beams with only physical dose constraint (MAN) and the initial MAN plan reoptimized with additional LET×D constraint (LETwMAN). The LETwBOO plans show superior physical dose and LET×D sparing. On average, the [mean, maximal] doses of OARs in LETwBOO are reduced by [2.85, 4.6] GyRBE from the MAN plans in the SBT cases and reduced by [0.9, 2.5] GyRBE in the H&N cases, while LETwMAN is comparable to MAN. cLET×Ds of PTVs are comparable in LETwBOO and LETwMAN, where c is a scaling factor of 0.04 μm/keV. On average, in the SBT cases, LETwBOO reduces the OAR [mean, maximal] cLET×D by [1.1, 2.9] Gy from the MAN plans, compared to the reduction by LETwMAN from MAN of [0.7, 1.7] Gy. In the H&N cases, LETwBOO reduces the OAR [mean, maximal] cLET×D by [0.8, 2.6] Gy from the MAN plans, compared to the reduction by LETwMAN from MAN of [0.3, 1.2] Gy. We developed a novel LET weighted BOO method for IMPT to generated plans with improved physical and biological OAR sparing compared with the plans unaccounted for biological effects from BOO.
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