Design and Performance of a High Spatial Resolution, Time-of-Flight PET Detector
Design and Performance of a High Spatial Resolution, Time-of-Flight PET Detector
复制标题
DOI：
10.1109/tns.2014.2302580
复制
发表时间：
2014-06-01
影响因子：
1.8
通讯作者：
Surti, Suleman
中科院分区：
文献类型：
--
作者：
Krishnamoorthy, Srilalan;LeGeyt, Benjamin;Surti, Suleman
本文介绍了一种高空间分辨率的正电子发射断层扫描（PET）探测器与飞行时间的能力的设计和性能。重点是高空间分辨率和灵敏度，我们最初评估了几个1.5 x 1.5和2.0 x 2.0 mm（2）和12-15 mm长的LYSO晶体的性能，这些晶体由几个适当尺寸的PMT读出。进行了评估反射器对检测器性能的影响的实验，最终检测器由32 x 32阵列的1.5 x 1.5 x 15 mm（3）LYSO晶体组成，该晶体填充有漫反射器，并由单个Hamamatsu 64通道多阳极PMT读出。这种设计使其紧凑，模块化，并提供了一个具有成本效益的解决方案，以获得出色的能量和定时分辨率。为了使读出信号的数量最小化，还开发了一种紧凑的前端读出电子设备，其沿每个正交方向沿着对阳极信号进行求和。检测器性能的实验评估表明，在检测器内的晶体的清晰的歧视。测量的平均能量分辨率（FWHM）为12.7 +/- 2.6%，平均符合时间分辨率（FWHM）为348 ps，证明适用于开发专用乳腺PET成像的高空间分辨率飞行时间扫描仪。
This paper describes the design and performance of a high spatial resolution positron emission tomography (PET) detector with time-of-flight capabilities. With an emphasis on high spatial resolution and sensitivity, we initially evaluated the performance of several 1.5 x 1.5 and 2.0 x 2.0 mm(2) and 12-15 mm long LYSO crystals read out by several appropriately sized PMTs. Experiments to evaluate the impact of reflector on detector performance were performed and the final detector consisted of a 32 x 32 array of 1.5 x 1.5 x 15 mm(3) LYSO crystals packed with a diffuse reflector and read out by a single Hamamatsu 64 channel multi-anode PMT. Such a design made it compact, modular and offered a cost-effective solution to obtaining excellent energy and timing resolution. To minimize the number of readout signals, a compact front-end readout electronics that summed anode signals along each of the orthogonal directions was also developed. Experimental evaluation of detector performance demonstrates clear discrimination of the crystals within the detector. An average energy resolution (FWHM) of 12.7 +/- 2.6% and average coincidence timing resolution (FWHM) of 348 ps was measured, demonstrating suitability for use in the development of a high spatial resolution time-of-flight scanner for dedicated breast PET imaging.