Mechanics of a mosquito bite with applications to microneedle design
Mechanics of a mosquito bite with applications to microneedle design
复制标题
DOI：
10.1088/1748-3182/3/4/046001
复制
发表时间：
2008-12-01
影响因子：
3.4
通讯作者：
Swaminathan, V.
中科院分区：
文献类型：
--
作者：
Ramasubramanian, M. K.;Barham, O. M.;Swaminathan, V.
已经使用高速视频（HSV）成像实验性地研究了埃及伊蚊（Aedes aegypti）类型的蚊子将纤维束插入皮肤中的力学，并且使用数学模型分析性地研究了该力学。纤维束是由韧性材料几丁质组成的聚合物微针。已经提出，除了欧拉压缩载荷之外，蚊子还施加非保守的从动力分量，以防止屈曲和穿透皮肤。此外，在插入过程中，围绕纤维束（阴唇）的保护鞘提供侧向支撑。提出的力学模型近似的分册作为一个细长的柱支撑的弹性基础（唇）进行非保守（贝克）和保守的欧拉载荷同时在年底。结果表明，由阴唇提供的侧支的成功渗透是必不可少的临界屈曲载荷增加了5倍。非保守随动器力的施加使屈曲载荷增加额外的20%，并且对于成功穿透可能是必要的，也可能不是必要的。实验结果表明阴唇的重要性已被引用，以验证模型的预测，除了在这项工作中提出的视频观察。这种理解可能有助于设计无痛针头插入系统，而不是小型化的皮下注射针头。
The mechanics of a fascicle insertion into the skin by a mosquito of the type aedes aegypti has been studied experimentally using high-speed video (HSV) imaging, and analytically using a mathematical model. The fascicle is a polymeric microneedle composed of a ductile material, chitin. It has been proposed that the mosquito applies a non-conservative follower force component in addition to the Euler compressive load in order to prevent buckling and penetrate the skin. In addition, the protective sheath surrounding the fascicle (labium) provides lateral support during insertion. The mechanics model presented approximates the fascicle as a slender column supported on an elastic foundation (labium) subjected to non-conservative (Beck) and conservative Euler loads simultaneously at the end. Results show that the lateral support of the fascicle provided by the labium is essential for successful penetration by increasing the critical buckling load by a factor of 5. The non-conservative follower force application increases the buckling load by an additional 20% and may or may not be necessary for successful penetration. Experimental results showing the importance of the labium have been cited to validate the model predictions, in addition to the video observations presented in this work. This understanding may be useful in designing painless needle insertion systems as opposed to miniaturized hypodermic needles.