Disparities in incidence of early- and late-onset colorectal cancer between Hispanics and Whites: A 10-year SEER database study
Disparities in incidence of early- and late-onset colorectal cancer between Hispanics and Whites: A 10-year SEER database study
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DOI：
10.1016/j.amjsurg.2017.03.035
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发表时间：
2018-04-01
影响因子：
3
通讯作者：
Nfonsam, Valentine
中科院分区：
文献类型：
--
作者：
Koblinski, Jenna;Jandova, Jana;Nfonsam, Valentine
背景：结直肠癌(CRC)发病率存在种族差异。在拉美裔美国人中，结直肠癌是2012年第二大最常见的癌症。方法：我们利用SEER数据库提取了2000至2010年间西班牙裔/白人结直肠癌的全国估计值。分析了早发(50岁；EO-Young)和晚发(50岁；10岁)病例的发病率、死亡率、性别和疾病分期的趋势。结果：西班牙裔结直肠癌的总发病率增加了48%。在这一民族中，LO-CRC的发病率增加了38%，EO-CRC的发病率增加了80%。西班牙裔和白人在这两个年龄组中显示出较高的远处肿瘤比例。总体趋势在男性和女性之间没有偏差。结论：尽管白人结直肠癌的发病率总体上有所下降，但在西班牙裔中却有所增加。虽然EO CRC的发病率在两个种族中都在增加，但LO CRC的发病率在西班牙裔中增加，而不是在白人中。这一数据表明，西班牙裔和白人在EO和LO结直肠癌的发病率上存在差异。由爱思唯尔公司出版。
Background: Racial disparities in incidence of colorectal cancer (CRC) exist. In Hispanics, CRC was the second most commonly diagnosed cancer in 2012.Methods: We abstracted the national estimates for Hispanics/Whites with CRC using the SEER database between 2000 and 2010. Trends in incidence, mortality, gender and stage of disease were analyzed for early-onset (age< 50; EO - young) and late-onset (age> 50; LO - old) cases.Results: The overall incidence of CRC increased by 48% in Hispanics. 38% increase in incidence of LO CRC and 80% increase in incidence of EO CRC was seen in this ethnic group. Hispanics and Whites showed higher percentage of distant tumors for both age groups. There was no deviation in overall trend between males and females.Conclusions: Although there is an overall decrease in incidence of CRC in Whites increase was seen in Hispanics. While incidence of EO CRC is increasing in both races, LO CRC incidence is increasing in Hispanics not in Whites. This data suggest that disparities in incidence of EO and LO CRC exist between Hispanics and Whites. Published by Elsevier Inc.