Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection
Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection
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DOI：
10.1111/jmp.12300
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发表时间：
2017-08-01
影响因子：
0.7
通讯作者：
Luo, Ma
中科院分区：
文献类型：
--
作者：
Li, Hongzhao;Omange, Robert W.;Luo, Ma
背景：了解自然控制HIV可能导致新的预防或治疗策略。在人类和恒河猴中发现了几种保护性主要组织相容性复合体（MHC）基因型。在这里，我们报告了毛里求斯食蟹猕猴（MCMs）的猴免疫缺陷病毒（SIV）控制器MHC基因型。方法：用SIVmac251感染12例mhc基因型mcm，监测病毒载量和CD4(+) t细胞计数。结果：2只M3M4基因型猕猴表现出最低的峰值病毒载量（血浆SIV RNA拷贝数/mL的对数），比大多数其他MHC单倍型组合的猕猴低近3个对数，设定点病毒载量低于RT-qPCR检测限水平（< 2个对数RNA拷贝数/mL）。它们保持健康的CD4(+) t细胞计数，每μ L血液中有500个细胞，而绝大多数其他猕猴的CD4计数低于这一水平。结论：M3M4 MHC基因型可能增强了mcm中SIV复制的控制。
Background: Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex (MHC) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus (SIV) controller MHC genotype in Mauritian cynomolgus macaques (MCMs).Methods: Twelve MHC-genotyped MCMs were infected with SIVmac251 and monitored for viral loads and CD4(+) T-cell counts.Results: Two macaques with M3M4 genotype exhibited the lowest peak viral loads (log plasma SIV RNA copies/mL), nearly 3 logs lower than those in most macaques with other MHC haplotype combinations, and set point viral loads below the level of detection limit by RT-qPCR (< 2 log RNA copies/mL). They maintained healthy CD4(+) T-cell counts of > 500 cells/mu L blood, while CD4 counts in the vast majority of other macaques were below this level.Conclusions: The M3M4 MHC genotype may confer enhanced control of SIV replication in MCMs.