5-Hydroxytryptamine mediates inhibitory postsynaptic potentials in rat dorsal raphe neurons
5-Hydroxytryptamine mediates inhibitory postsynaptic potentials in rat dorsal raphe neurons
复制标题
5-羟色胺介导大鼠中缝背侧神经元的抑制性突触后电位
DOI：
10.1016/0304-3940(85)90099-0
复制
发表时间：
1985
影响因子：
2.5
通讯作者：
H. Higashi
中科院分区：
文献类型：
--
作者：
M. Yoshimura;H. Higashi
在大鼠中缝背侧神经元中，局部电刺激引起与膜电导增加相关的缓慢抑制性突触后电位（IPSP）。根据文献中的数据，该 IPSP 可能是由循环抑制电路引起的。 5-羟色胺 (5-HT) 的应用引起细胞膜超极化，也与膜电导增加有关。这两种反应都可以被麦角酰二乙胺或美西麦角消除，并被丙咪嗪增强。反应的反转电位处于相同的-95 mV水平，这表明膜钾电导的增加是两种反应的机制。这些数据表明 5-HT 可能是局灶刺激诱发 IPSP 的介质。
In rat dorsal raphe neurons, focal electrical stimulation elicited a slow inhibitory postsynaptic potential (IPSP) associated with increased membrane conductance. On the basis of data in the literature this IPSP is presumably caused by a recurrent inhibitory circuit. 5-Hydroxytryptamine (5-HT) application caused a hyperpolarization of the cell membrane, also associated with increased membrane conductance. Both responses could be abolished by lysergic acid diethylamide or methysergide, and enhanced by imipramine. The reversal potentials for the responses were at the same level of −95 mV which suggests an increase in membrane potassium conductance as the mechanism of both responses. These data suggest that 5-HT may be the mediator of the IPSP evoked by focal stimulation.