Mechanisms of cancer-associated glycosylation changes
Mechanisms of cancer-associated glycosylation changes
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DOI：
10.2741/3951
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Chiricolo, Mariella
中科院分区：
文献类型：
--
作者：
Dall'Olio, Fabio;Malagolini, Nadia;Chiricolo, Mariella
细胞膜糖缀合物经历肿瘤转化的结果的特征性变化。癌症相关的碳水化合物结构通过改变细胞-细胞和细胞-环境相互作用在癌症进展中起关键作用。在这篇综述中，我们将讨论一些最相关的癌症相关的碳水化合物结构，包括N-连接链的β 1，6-分支，唾液酸刘易斯抗原，α 2，6-唾液酸化乳糖胺，与神经节苷脂相关的抗原和神经节苷脂。我们将描述导致这些结构表达的机制及其与糖结合分子（如选择素和半乳糖凝集素）的相互作用。最后，我们将讨论细胞的糖基化机制是如何通过信号转导途径、表观遗传机制和缺氧反应来控制的。
Cell membrane glycoconjugates undergo characteristic changes as a consequence of neoplastic transformation. The cancer-associated carbohydrate structures play key roles in cancer progression by altering the cell-cell and cell-environment interactions. In this review, we will discuss some of the most relevant cancer-associated carbohydrate structures, including the beta 1,6-branching of N-linked chains, the sialyl Lewis antigens, the alpha 2,6-sialylated lactosamine, the Thomsen-Friedenreich-related antigens and gangliosides. We will describe the mechanisms leading to the expression of these structures and their interactions with sugar binding molecules, such as selectins and galectins. Finally, we will discuss how the glycosylation machinery of the cell is controlled by signal transduction pathways, epigenetic mechanisms and responds to hypoxia.