Comparison of Gd-BOPTA with Gd-DTPA in MR imaging of rat liver.
Comparison of Gd-BOPTA with Gd-DTPA in MR imaging of rat liver.
复制标题
Gd-BOPTA 与 Gd-DTPA 在大鼠肝脏 MR 成像中的比较。
DOI：
10.1148/radiology.176.1.2353112
复制
发表时间：
1990
期刊：
影响因子：
19.7
通讯作者：
E. Felder
中科院分区：
文献类型：
--
作者：
P. Pavone;G. Patrizio;C. Buoni;E. Tettamanti;R. Passariello;C. Musu;P. Tirone;E. Felder
研究了一种具有高胆汁排泄率的新型亲脂化合物苯氧丙酸四乙酸钆（BOPTA）作为肝特异性磁共振造影剂，并与Gd-DTPA（二乙烯三胺五乙酸）在正常大鼠磁共振成像中的表现进行了比较。在给药剂量分别为0.25、0.5和1.0 mmol/kg的造影剂前后获得的t1加权自旋回波图像显示，Gd-BOPTA比Gd-DTPA对肝脏的增强更大，且剂量越低，优势越明显。与Gd-DTPA相比，注射0.1和0.5 mmol/kg剂量的造影剂后，在大鼠肝实质零值处倒置恢复序列获得的图像更能证明Gd-BOPTA对肝脏的增强作用更大，持续时间更长。Gd-BOPTA是一种潜在的良好造影剂，用于获得肝脏长时间增强，允许在较长时间内获得常规t1加权图像。
A new lipophilic compound, gadolinium benzyloxypropionictetraacetate (BOPTA), with a high rate of biliary excretion was assessed as a magnetic resonance (MR) hepatospecific contrast-enhancing agent and compared with Gd-DTPA (diethylenetriaminepentaacetic acid) in MR imaging of normal rats. T1-weighted spin-echo images obtained before and after administration of each contrast agent at doses of 0.25, 0.5, and 1.0 mmol/kg showed greater enhancement of the liver with Gd-BOPTA than with Gd-DTPA, with the advantage more evident at lower doses. Images obtained with an inversion recovery sequence at the null value of rat liver parenchyma after injection of 0.1- and 0.5-mmol/kg doses of the contrast agent provided better evidence of the greater and longer-lasting hepatic enhancement due to Gd-BOPTA when compared with that of Gd-DTPA. Gd-BOPTA is a potentially good contrast agent for obtaining prolonged enhancement of the liver, permitting studies during the long time needed to acquire conventional T1-weighted images.