Estimation of cerebral blood flow from thermal measurement.
Estimation of cerebral blood flow from thermal measurement.
复制标题
通过热测量估计脑血流量。
DOI：
10.1115/1.2792273
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Jones,SC
中科院分区：
文献类型：
--
作者：
Wei,D;Saidel,GM;Jones,SC
已经开发出一种热方法来通过自校准来量化连续灌注变化。热探针和组织的动态一维生物传热模型描述了系统对连续或瞬态加热的响应。模型与实验数据的非线性最小二乘拟合产生基线灌注和其他模型参数的估计。对于模型的部分解析解，最佳估计过程比模型系统的整体数值解效率高两个数量级。实验数据用于估计灌注和温度测量之间的操作关系。还提出了一种新程序来获取系统的动态响应，以连续测量灌注。
A thermal method has been developed to quantify continuous perfusion changes with self-calibration. A dynamic, one-dimensional bio-heat transfer model of the thermal probe and tissue describes the system response to either continuous or transient heating. A nonlinear least-squares fit of the model to experimental data yields estimates of the baseline perfusion and other model parameters. With a partial analytical solution of the model, the optimal estimation procedure is two orders of magnitude more efficient than with a total numerical solution of the model system. Experimental data is used to estimate the operating relations between perfusion and the temperature measurement. A new procedure has also been presented to obtain the dynamic response of the system for continuous measurement of perfusion.