BTBD7 accelerates the epithelial-mesenchymal transition, proliferation and invasion of prostate cancer cells.
BTBD7 accelerates the epithelial-mesenchymal transition, proliferation and invasion of prostate cancer cells.
复制标题
BTBD7 加速前列腺癌细胞的上皮间质转化、增殖和侵袭。
DOI：
--
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Houqiang Xu
中科院分区：
文献类型：
--
作者：
Bin Chen;Chang Liu;Guohui Bai;Yuhang Zhu;Houqiang Xu
Purpose To investigate the potential function of BTBD7 in prostate cancer (PCa) development and the underlying molecular mechanism. Methods Serum levels of BTBD7 in PCa patients were examined by qRT-PCR. Regulatory effects of BTBD7 on viability and invasiveness were detected by CCK-8 and Transwell assay, respectively. Moreover, Western blot analysis was conducted to examine protein levels of epithelial-mesenchymal transition (EMT) markers (E-cadherin and N-cadherin) in PCa cells intervened by BTBD7. Results Serum level of BTBD7 was increased in PCa patients, especially those with Gleason score ≥8 or TNM staging Ⅲ+Ⅳ. Knockdown of BTBD7 attenuated the viability and invasiveness of PCa cells, which upregulated E-cadherin and downregulated N-cadherin. Conclusion Serum level of BTBD7 increases in PCa patients. It accelerates PCa development by triggering proliferative and invasive potentials, as well as EMT.
