When ribosomes go bad: diseases of ribosome biogenesis.
When ribosomes go bad: diseases of ribosome biogenesis.
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DOI:
10.1039/b919670f
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发表时间:
2010-03
影响因子:
--
通讯作者:
Baserga SJ
中科院分区:
文献类型:
--
作者:
Freed EF;Bleichert F;Dutca LM;Baserga SJ
Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.
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