When ribosomes go bad: diseases of ribosome biogenesis.

When ribosomes go bad: diseases of ribosome biogenesis.
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DOI:
10.1039/b919670f
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发表时间:
2010-03
影响因子:
--
通讯作者:
Baserga SJ
Baserga SJ
中科院分区:
生物3区
文献类型:
--
作者:
Freed EF;Bleichert F;Dutca LM;Baserga SJ

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核糖体对细胞生长和存活至关重要。直到最近,人们还认为,由于这些复合物的本质,核糖体或核糖体生物发生因子的突变将是致命的。然而,在过去的几十年里,已经发现了许多核糖体生物合成的疾病。它仍然是一个挑战,在该领域阐明其背后的分子机制。
Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.
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