Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
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补充核黄素对核黄素水平低的老年人血浆同型半胱氨酸的影响
DOI：
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发表时间：
2002
影响因子：
4.7
通讯作者：
J. Scott
中科院分区：
文献类型：
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作者：
M. C. McKinley;H. McNulty;J. Mcpartlin;J. Strain;J. Scott
目的：探讨补充核黄素对核黄素状态不佳的健康老年人血浆同型半胱氨酸（tHcy）浓度的影响。设计：一项双盲、随机、安慰剂对照的核黄素补充试验。背景：在北爱尔兰进行基于社区的研究。对象：从101名健康老年人的筛选样本中，52名核黄素状态次优（红细胞谷胱甘肽还原酶激活系数，EGRAC≥1.20）的老年人被邀请参加研究。干预：干预包括两个部分。第一部分是为期12周的随机双盲、安慰剂对照的核黄素干预（1.6 mg/天）。在第一部分完成后，安慰剂组继续进行研究的第二部分，其中包括补充叶酸（400微克/天）6周，然后补充叶酸和核黄素（1.6毫克/天）12周，补充后有16周的洗脱期。第2部分的目的是：(a)解决同型半胱氨酸对核黄素反应的降低可能被叶酸更大的作用所掩盖的可能性，并且，一旦叶酸状态优化，同型半胱氨酸对核黄素的依赖可能出现；(b)证明这些受试者的同型半胱氨酸浓度可以通过营养干预来降低。结果：尽管在研究的第一部分和第二部分中，补充核黄素显著改善了核黄素状态（P<0.001），但tHcy浓度未受影响（P=0.719）。相比之下，叶酸补充剂（研究部分2）导致同型半胱氨酸降低19.6% （P=0.001）。结论：尽管tHcy对核黄素有代谢依赖性，但即使在核黄素状态不理想的情况下，tHcy也不是一种有效的同型半胱氨酸降低剂。
Objective: To investigate the effect of riboflavin supplementation on plasma homocysteine (tHcy) concentrations in healthy elderly people with sub-optimal riboflavin status.Design: A double-blind, randomized, placebo-controlled riboflavin supplementation trial.Setting: Community based study in Northern Ireland.Subjects: From a screening sample of 101 healthy elderly people, 52 had sub-optimal riboflavin status (erythrocyte glutathione reductase activation coefficient, EGRAC≥1.20) and were invited to participate in the study.Intervention: The intervention had two parts. Part 1 was a 12 week randomized double blind, placebo-controlled intervention with riboflavin (1.6 mg/day). Following completion of part 1, the placebo group went on to part 2 of the study which involved supplementation with folic acid (400 µg/day) for 6 weeks followed by folic acid and riboflavin (1.6 mg/day) for a further 12 weeks, with a 16 week washout period post-supplementation. The purpose of part 2 was: (a) to address the possibility that homocysteine-lowering in response to riboflavin may be obscured by a much greater effect of folate, and that, once folate status was optimized, a dependence of homocysteine on riboflavin might emerge; and (b) to demonstrate that these subjects had homocysteine concentrations which could be lowered by nutritional intervention.Results: Although riboflavin supplementation significantly improved riboflavin status in both parts 1 and 2 of the study (P<0.001 for each), tHcy concentrations were unaffected (P=0.719). In contrast, folic acid supplementation (study part 2) resulted in a homocysteine lowering of 19.6% (P=0.001).Conclusion: Despite the metabolic dependency of tHcy on riboflavin, it did not prove to be an effective homocysteine-lowering agent, even in the face of sub-optimal riboflavin status.