Spina bifida, 677T→C mutation, and role of folate
Spina bifida, 677T→C mutation, and role of folate
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脊柱裂、677T→C 突变和叶酸的作用
DOI：
10.1016/s0140-6736(95)92865-0
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
P. Mastroiacovo
中科院分区：
文献类型：
--
作者：
R. Franchis;G. Sebastio;C. Mandato;G. Andria;P. Mastroiacovo
人们可以推测，荷尔蒙有利于激素依赖、基因进化较少的克隆的扩张，这些克隆可能更容易治愈。值得一提的是，接受激素治疗的患者一年看两次医生，因此他们有一种系统的筛查形式。4在接受HRT的患者中，由于早期发现和固有的生物因素，乳腺癌的潜在有利预后需要得到更好的定义，并应被视为支持对绝经后患者广泛使用HRT的重要论据。
One could speculate that hormones favour the expansion of hormone-dependent, genetically less evolved clones that might be more amenable to cure. It is also worth mentioning that patients receiving hormonal therapy see their doctor twice a year and thus they have a form of systematic screening. 4 The potentially favourable prognosis of breast cancers that develop in patients on HRT, both because of early detection and because of inherent biological factors, needs to be better defined, and should be recognised as an important argument in favour of wide use of HRT for post-menopausal patients.