Nano-assembly of nanodiamonds by conjugation to actin filaments
Nano-assembly of nanodiamonds by conjugation to actin filaments
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DOI：
10.1002/jbio.201500167
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发表时间：
2016-03-01
影响因子：
2.8
通讯作者：
Brown, Louise J.
中科院分区：
文献类型：
--
作者：
Bradac, Carlo;Say, Jana M.;Brown, Louise J.
荧光纳米金刚石（ND）是非凡的物体。它们具有独特的机械和光学特性以及高表面积和可控的表面反应性。它们无毒，因此适合在生物环境中使用。 ND 也很容易获得并且商业价格低廉。在这里，展示了控制和定制其表面化学的卓越能力。小而明亮的金刚石纳米晶体（尺寸类似于 30 nm）与肌动蛋白蛋白丝（长度类似于 3-7 μm）缀合。与肌动蛋白丝的缀合具有极高的选择性和高度的靶标特异性。这些独特的功能，加上相对简单的共轭靶向方法，使功能化纳米金刚石成为生物医学和量子纳米技术中强大且多功能的平台。介绍并讨论了各种应用，从使用 ND 作为优异的生物标记，到潜在地开发用于制造跨生物/固态界面的混合量子器件的新型自下而上方法。
Fluorescent nanodiamonds (NDs) are remarkable objects. They possess unique mechanical and optical properties combined with high surface areas and controllable surface reactivity. They are non-toxic and hence suited for use in biological environments. NDs are also readily available and commercially inexpensive. Here, the exceptional capability of controlling and tailoring their surface chemistry is demonstrated. Small, bright diamond nanocrystals (size similar to 30 nm) are conjugated to protein filaments of actin (length similar to 3-7 mu m). The conjugation to actin filaments is extremely selective and highly target-specific. These unique features, together with the relative simplicity of the conjugation-targeting method, make functionalised nanodiamonds a powerful and versatile platform in biomedicine and quantum nanotechnologies. Applications ranging from using NDs as superior biological markers to, potentially, developing novel bottom-up approaches for the fabrication of hybrid quantum devices that would bridge across the bio/solid-state interface are presented and discussed.