Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system.
Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system.
复制标题
中空纤维组合葡萄糖响应凝胶技术作为体内无电子胰岛素输送系统。
DOI：
10.1038/s42003-020-1026-x
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Suganami T.
中科院分区：
文献类型：
--
作者：
Matsumoto A;Kuwata H;Kimura S;Matsumoto H;Ochi K;Moro-oka Y;Watanabe A;Yamada H;Ishii H;Miyazawa T;Chen S;Baba T;Yoshida H;Nakamura T;Inoue H;Ogawa Y;Tanaka M;Miyahara Y;Suganami T.
越来越多的证据表明，不仅血糖水平持续升高，而且血糖波动也是糖尿病并发症和死亡率的关键决定因素。目前的闭环胰岛素治疗选择仅限于使用基于电子的系统，尽管它带来了一些成本高的技术问题。在这里，我们展示了一种无电子的，基于合成硼酸盐凝胶的胰岛素扩散控制装置技术，该技术可以科普葡萄糖波动，并可能解决电子衍生的问题。将凝胶与血液透析中空纤维组合，并按比例适合于大鼠，作为皮下植入的胰岛素扩散活性位点，其方式依赖于皮下葡萄糖。连续葡萄糖监测测试显示，我们的装置不仅使大鼠的平均葡萄糖水平正常化，而且显著改善了一天时间尺度上的波动，而不诱导低血糖。凭借固有的稳定性，扩散依赖的可扩展性以及长达一周的急性葡萄糖反应性，我们的技术可以为当前基于电子的方法提供低成本的替代方案。
Accumulating evidence demonstrates that not only sustained elevation of blood glucose levels but also the glucose fluctuation represents key determinants for diabetic complications and mortality. Current closed-loop insulin therapy option is limited to the use of electronics-based systems, although it poses some technical issues with high cost. Here we demonstrate an electronics-free, synthetic boronate gel-based insulin-diffusion-control device technology that can cope with glucose fluctuations and potentially address the electronics-derived issues. The gel was combined with hemodialysis hollow fibers and scaled suitable for rats, serving as a subcutaneously implantable, insulin-diffusion-active site in a manner dependent on the subcutaneous glucose. Continuous glucose monitoring tests revealed that our device not only normalizes average glucose level of rats, but also markedly ameliorates the fluctuations over timescale of a day without inducing hypoglycemia. With inherent stability, diffusion-dependent scalability, and week-long & acute glucose-responsiveness, our technology may offer a low-cost alternative to current electronics-based approaches.