Compensatory Enlargement of Ossabaw Miniature Swine Coronary Arteries in Diffuse Atherosclerosis.
Compensatory Enlargement of Ossabaw Miniature Swine Coronary Arteries in Diffuse Atherosclerosis.
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DOI：
10.1016/j.ijcha.2014.11.003
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发表时间：
2015-03-01
影响因子：
2.9
通讯作者：
Kassab, Ghassan S
中科院分区：
文献类型：
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作者：
Choy, Jenny S;Luo, Tong;Huo, Yunlong;Wischgoll, Thomas;Schultz, Kyle;Teague, Shawn D;Sturek, Michael;Kassab, Ghassan S
对人类和非人类灵长类动物的研究证实，在局灶性狭窄的情况下，冠状血管会出现代偿性扩张或正性重塑（格拉戈夫现象）。据我们所知，这是第一项记录在没有严重局灶性狭窄的情况下患有弥漫性冠状动脉疾病（DCAD）的代谢综合征动物模型中动脉扩张的研究。两组不同的 Ossabaw 小型猪分别饲喂 4 个月（第一组）和 12 个月（第二组）的高脂肪致动脉粥样硬化饮食。第一组（6 头猪）在基线和高脂肪饮食 4 个月后接受了对比增强计算机断层扫描 (CCTA) 和血管内超声 (IVUS)，而第二组（7 头猪）在高脂肪饮食 12 个月后仅接受了 IVUS。第一组左前降支 (LAD)、左回旋支 (LCX) 和右冠状动脉 (RCA) 的 IVUS 测量结果显示，与基线相比，其管腔横截面积 (CSA) 平均分别增加了 25.8%、11.4% 和 43.4%。第二组 LAD 的流明 CSA 值介于第一组的基线值和 4 个月值之间。IVUS 和 CCTA 测量结果显示出类似的趋势和正相关。血流储备分数 (FFR) 基线时为 0.91 ± 0.07，4 个月时为 0.93 ± 0.05，LAD、LCX 和 RCA 分别仅有 2.2%、1.6% 和 1% 狭窄。在 DCAD 动物模型中，狭窄百分比与管腔 CSA 之间的关系显示出经典的 Glagov 现象。
Studies in human and non-human primates have confirmed the compensatory enlargement or positive remodeling (Glagov phenomenon) of coronary vessels in the presence of focal stenosis. To our knowledge, this is the first study to document arterial enlargement in a metabolic syndrome animal model with diffuse coronary artery disease (DCAD) in the absence of severe focal stenosis. Two different groups of Ossabaw miniature pigs were fed a high fat atherogenic diet for 4 months (Group I) and 12 months (Group II), respectively. Group I (6 pigs) underwent contrast enhanced computed tomographic angiography (CCTA) and intravascular ultrasound (IVUS) at baseline and after 4 months of high fat diet, whereas Group II (7 pigs) underwent only IVUS at 12 months of high fat diet. IVUS measurements of the left anterior descending (LAD), left circumflex (LCX) and right coronary (RCA) arteries in Group I showed an average increase in their lumen cross-sectional areas (CSA) of 25.8%, 11.4%, and 43.4%, respectively, as compared to baseline. The lumen CSA values of LAD in Group II were found to be between the baseline and 4 month values in Group I. IVUS and CCTA measurements showed a similar trend and positive correlation. Fractional flow reserve (FFR) was 0.91 ± 0.07 at baseline and 0.93 ± 0.05 at 4 months with only 2.2%, 1.6% and 1% stenosis in the LAD, LCX and RCA, respectively. The relation between percent stenosis and lumen CSA shows a classical Glagov phenomenon in this animal model of DCAD.