A New Model for Predicting Hypothyroidism After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma.
A New Model for Predicting Hypothyroidism After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma.
复制标题
DOI：
10.3389/fonc.2020.551255
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Tang LL
中科院分区：
文献类型：
--
作者：
Peng L;Mao YP;Huang CL;Guo R;Ma J;Wen WP;Tang LL
建立鼻咽癌调强放疗（IMRT）后甲状腺功能减退（HT）风险预测模型，并提出相应的剂量限制建议。回顾性分析了2011年至2015年期间接受治疗的NPC患者。HT的定义是促甲状腺激素水平异常高。计算剂量学参数Vx（甲状腺体积接受x戈伊以上照射的百分比）和Va，B（甲状腺体积接受>a戈伊而≤B戈伊照射的百分比）。主要终点是IMRT后前2年内HT的发展。使用最小绝对收缩和选择运算符以及多变量逻辑回归来识别HT的预测因素。共有545名患者被纳入分析，中位随访时间为36个月。在545例患者中，138例在2年内发生HT，HT的2年发生率为25.3%。甲状腺体积>20 cm 3者2年HT发生率为11.7%（16/137），甲状腺体积≤20 cm 3、V30、60 ≤ 80%者2年HT发生率为19.9%（33/166）;甲状腺体积≤20 cm 3，V30，60 > 80%者，2年HT发生率为36.8%（89/242）。甲状腺体积和V30、60是预测鼻咽癌调强放疗后HT的可靠指标。对于甲状腺体积≤20 cm 3的患者，甲状腺V30，60 ≤ 80%可能是IMRT计划中采用的有用剂量限制。
To develop a model that can predict the risk of hypothyroidism (HT) after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC), and to accordingly recommend dose constraints. NPC patients treated between 2011 and 2015 were retrospectively reviewed. HT was defined by an abnormally high level of thyrotropin. The dosimetry parameters Vx (percentage of thyroid volume receiving more than x Gy of radiation) and Va,b (percentage of thyroid volume receiving >a Gy, while ≤b Gy radiation) were calculated. The primary endpoint was the development of HT within the first 2 years after IMRT. The least absolute shrinkage and selection operator and multivariate logistic regression were used to identify predictors of HT. A total of 545 patients were included in the analyses, with a median follow-up of 36 months. Of the 545 patients, 138 developed HT within 2 years, and the 2-year incidence of HT was 25.3%. In patients with thyroid volume >20 cm3, the 2-year incidence of HT was 11.7% (16/137); in patients with thyroid volume ≤20 cm3 and V30,60 ≤ 80%, the 2-year HT incidence was 19.9% (33/166); in patients with thyroid volume ≤20 cm3 and V30,60 > 80%, the 2-year incidence of HT was 36.8% (89/242). Thyroid volume and V30,60 could be reliable predictors of HT after IMRT for NPC. For patients with thyroid volume ≤20 cm3, thyroid V30,60 ≤ 80% might be a useful dose constraint to adopt during IMRT planning.
登录
查看更多内容
影响因子：
2.9
作者：
Xu, Yumei;Shao, Zhiying;Zhang, Longzhen
通讯作者：
Zhang, Longzhen
影响因子：
6.6
作者：
Garber, Jeffrey R.;Cobin, Rhoda H.;Woeber, Kenneth A.
通讯作者：
Woeber, Kenneth A.
影响因子：
5.8
作者：
Razvi, Salman;Shakoor, Abdul;Pearce, Simon H. S.
通讯作者：
Pearce, Simon H. S.
影响因子：
2.6
作者：
Luo, Ren;Li, Mei;Lin, Zhixiong
通讯作者：
Lin, Zhixiong
DOI：
10.1016/j.ijrobp.2017.03.007
发表时间：
2017-07-01
影响因子：
7
作者：
Sommat, Kiattisa;Ong, Whee Sze;Fong, Kam Weng
通讯作者：
Fong, Kam Weng