Insights into collective cell behaviour from populations of coupled chemical oscillators.
Insights into collective cell behaviour from populations of coupled chemical oscillators.
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DOI：
10.1039/c5cp01964h
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
A. Taylor;M. Tinsley;K. Showalter
中科院分区：
文献类型：
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作者：
A. Taylor;M. Tinsley;K. Showalter
生物系统，如酵母，在细胞之间的化学交流的驱动下显示出协调的活动。在这里，我们展示了耦合化学振荡器的实验如何提供对细胞系统中集体行为的洞察。描述了两种耦合振荡器的方法：化学物种与周围溶液的交换和计算机控制的光敏催化剂照明。观察到的集体行为包括同步、动态群体感应(一种依赖于密度的向全种群振荡的转变)和嵌合态，在嵌合态中，振荡者自发地分裂为相干和非相干群。不同类型的行为的核心是细胞内的自催化信号和影响自催化生长的细胞间通信机制。
Biological systems such as yeast show coordinated activity driven by chemical communication between cells. Here, we show how experiments with coupled chemical oscillators can provide insights into collective behaviour in cellular systems. Two methods of coupling the oscillators are described: exchange of chemical species with the surrounding solution and computer-controlled illumination of a light-sensitive catalyst. The collective behaviour observed includes synchronisation, dynamical quorum sensing (a density dependent transition to population-wide oscillations), and chimera states, where oscillators spontaneously split into coherent and incoherent groups. At the core of the different types of behaviour lies an intracellular autocatalytic signal and an intercellular communication mechanism that influences the autocatalytic growth.