Role of motility in adherence to and invasion of a fish cell line by Vibrio anguillarum
Role of motility in adherence to and invasion of a fish cell line by Vibrio anguillarum
复制标题
DOI：
10.1128/jb.182.8.2326-2328.2000
复制
发表时间：
2000-04-01
影响因子：
3.2
通讯作者：
Milton, DL
中科院分区：
文献类型：
--
作者：
Ormonde, P;Hörstedt, P;Milton, DL
为了进一步了解鳗弧菌鞭毛在致病性中的作用，利用大鳞鲑胚胎细胞系分析了等基因运动突变体的侵袭和粘附特性。粘附不受影响，但侵袭的细胞系显着减少nonmotile或部分motile突变体，和趋化突变体是高侵袭性的。这些结果表明，在体内和体外，主动运动有助于鳗弧菌的入侵。
To understand further the role of the flagellum of Vibrio anguillarum in virulence, invasive and adhesive properties of isogenic motility mutants were analyzed by using a chinook salmon embryo cell line. Adhesion was unaffected but invasion of the cell line was significantly decreased in nonmotile or partially motile mutants, and the chemotactic mutant was hyperinvasive. These results suggest that active motility aids invasion by V. anguillarum, both in vivo and in vitro.