Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels
Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels
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DOI：
10.1038/aps.2015.81
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发表时间：
2015-12-01
影响因子：
8.2
通讯作者：
Jia, Wei-ping
中科院分区：
文献类型：
--
作者：
Luo, Yu-qi;Ma, Xiao-jing;Jia, Wei-ping
目的：骨钙素参与动物模型和人类非酒精性脂肪性肝病（NAFLD）的进展。在这项研究中，我们调查了血清骨钙素水平和NAFLD在绝经后women.Methods的关系：共733绝经后妇女（年龄范围：41-78岁）与正常血糖水平纳入这项横断面研究。服用降脂或降压药物的女性被排除在外。血清骨钙素水平采用电化学发光免疫分析法进行评估。通过超声检查评估每个受试者的NAFLD进展程度。结果：所有受试者血清骨钙素水平中位数为21.99 ng/mL（四分位距：17.84-26.55 ng/mL）。NAFLD受试者血清骨钙素水平（18.39 ng/mL;范围：16.03-23.64 ng/mL）显著低于非NAFLD受试者（22.31 ng/mL;范围：18.55-27.06 ng/mL; P
Aim: Osteocalcin is involved in the progression of nonalcoholic fatty liver disease (NAFLD) in animal models and humans. In this study we investigated the relationship between serum osteocalcin levels and NAFLD in postmenopausal Chinese women.Methods: A total of 733 postmenopausal women (age range: 41-78 years) with normal blood glucose levels were enrolled in this cross-sectional study. Women taking lipid-lowering or anti-hypertensive drugs were excluded. Serum osteocalcin levels were assessed using an electrochemiluminescence immunoassay. The degree of NAFLD progression for each subject was assessed through ultrasonography. The fatty liver index (FLI) of each subject was calculated to quantify the degree of liver steatosis.Results: The median level of serum osteocalcin for all subjects enrolled was 21.99 ng/mL (interquartile range: 17.84-26.55 ng/mL). Subjects with NAFLD had significantly lower serum osteocalcin levels (18.39 ng/mL; range: 16.03-23.64 ng/mL) compared with those without NAFLD (22.31 ng/mL; range: 18.55-27.06 ng/mL; P