CHLORTHALIDONE PROMOTES MINERAL RETENTION IN PATIENTS WITH IDIOPATHIC HYPERCALCIURIA
CHLORTHALIDONE PROMOTES MINERAL RETENTION IN PATIENTS WITH IDIOPATHIC HYPERCALCIURIA
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DOI：
10.1038/ki.1988.122
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发表时间：
1988-06-01
影响因子：
19.6
通讯作者：
FAVUS, MJ
中科院分区：
文献类型：
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作者：
COE, FL;PARKS, JH;FAVUS, MJ
在7例严重特发性高钙尿症和复发性草酸钙肾结石患者中，我们确定了氯噻酮或三氯噻嗪长期治疗对矿物质平衡的影响，这些药物被广泛用于降低尿钙丢失和减少结石复发。每个人在未经治疗的情况下每天排出超过350毫克的钙，我们在治疗前和治疗后三到六个月进行了两次研究。与治疗前相比，药物减少了肠道钙吸收，但它们减少尿钙流失更多，因此钙潴留增加。磷酸盐保留也增加。骨化三醇、甲状旁腺激素、钙、磷酸盐和镁的血清水平不变。至少在这种类型的患者中，氯噻酮和三氯噻嗪似乎是理想的治疗方法，可以降低尿钙，增加钙和磷的潴留。不太严重的高钙尿症患者是否有这种反应尚不清楚。
In seven patients with severe idiopathic hypercalciuria and recurrent calcium oxalate nephrolithiasis, we have determined the effects on mineral balance of chronic treatment with chlorthalidone or trichlormethiazide, drugs that are widely used to lower urine calcium losses and reduce stone recurrence. Each person excreted above 350 mg of calcium daily while untreated, and weas studied twice, before and after three to six months of treatment. Compared to pretreatment, the drugs reduced intestinal calcium absorption; but they reduced urine calcium loss even more, so calcium retention increased. Phosphate retention also increasesd. Serum levels of calcitriol, parathyroid hormone, calcium, phosphate, and magnesium were unchanged. At least in patients of this type, chlorthalidone and trichlormethiazide seem ideal treatments, that lower urine calcium yet increase calcium and phosphate retention. Whether patietns with less severe hypercalciuria respond this way is unknown.