Aerobic exercise and plasma beta endorphin levels in patients with migrainous headache without aura
Aerobic exercise and plasma beta endorphin levels in patients with migrainous headache without aura
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DOI：
10.1046/j.1468-2982.2003.00624.x
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发表时间：
2003-12-01
期刊：
影响因子：
4.9
通讯作者：
Ersoy, AÖ
中科院分区：
文献类型：
--
作者：
Köseoglu, E;Akboyraz, A;Ersoy, AÖ
本研究旨在评价血浆β-内啡肽水平和运动对偏头痛的影响。40例无先兆偏头痛(MWOA)患者首先在跑步机上锻炼，然后被要求继续进行为期6周的有氧家庭锻炼计划。在评估方面，基础血浆β-内啡肽水平与最近一个月发作的总持续时间呈负相关(P=0.01)。研究发现，锻炼对偏头痛的所有参数都有好处(P<；0.0001)，在跑步机练习(P<；0.0001)和家庭锻炼计划之后(P<；0.0001)和家庭锻炼计划之后，除了四名没有定期参加该计划的患者(P<；0.0001)外，锻炼对偏头痛的所有参数都有有益的影响。头痛参数的任何变化都与β-内啡肽水平的变化无关。然而，运动前β内啡肽水平与发作次数和发作总持续时间的变化呈负相关(P=0.0001)，与运动引起的β内啡肽水平变化也呈负相关(P<0.05)。因此，这项研究强调了运动对偏头痛的有益效果，特别是在基础β内啡肽水平较低的患者。
This study aims to evaluate the effects of plasma beta endorphin level and exercise on migrainous headache. Forty patients with migrainous headache without aura (MWOA), firstly exercised on a treadmill and afterwards were asked to continue an aerobic home exercise program for six weeks. On evaluation, basal plasma beta endorphin level was negatively correlated with total duration of attacks in the last month period (P = 0.01). Exercise was found to have beneficial effects on all migraine parameters (P < 0.0001) and to increase beta endorphin levels after the treadmill practice (P < 0.0001) and after the home exercise program except four patients not regularly attended to the program (P < 0.0001). Any of the changes in headache parameters was not correlated with the change in beta endorphin level. However, pre-exercise beta endorphin level was found to be negatively correlated with the changes in the number of attacks (P < 0.05) and total duration of attacks (P = 0.01) and also with the change in beta endorphin level due to exercise (P < 0.0001). As a result, this study emphasizes the beneficial effect of exercise on migrainous headache, especially in patients with lower basal beta endorphin level.