Making nanofibres of mucoadhesive polymer blends for vaginal therapies
Making nanofibres of mucoadhesive polymer blends for vaginal therapies
复制标题
DOI：
10.1016/j.eurpolymj.2015.07.006
复制
发表时间：
2015-09-01
影响因子：
6
通讯作者：
Edirisinghe, Mohan
中科院分区：
文献类型：
--
作者：
Brako, Francis;Raimi-Abraham, Bahijja;Edirisinghe, Mohan
来自粘膜粘附聚合物的纳米纤维可以将其材料性质与独特的结构特征结合联合收割机，以获得上级药物递送性能。然而，由于它们的链结构，显著比例的粘膜粘附聚合物如多糖不能容易地纺成纤维。在这项研究中，我们证明了使用聚合物共混物制备纳米纤维，提供大量的粘膜粘附能力的可能性。通过在不同的工作压力和24，000rpm的旋转速度下加压回转，获得来自四种不同聚合物的纤维。电子显微镜表明，成功地生产了直径小于100 nm以上的结构明确的纤维。建立了物理性质和纤维特性之间的定量关系，同时证实纤维组合物含有可能赋予粘膜粘附性质的特征。最后，纹理分析和原子力显微镜的组合被用来验证转化为纳米纤维结构的聚合物粉末的好处，就粘膜粘附潜力而言。(C)2015作者由爱思唯尔有限公司发布
Nanofibres from mucoadhesive polymers could combine their material properties with unique structural characteristics for superior drug delivery performance. However, due to their chain structure a significant proportion of mucoadhesive polymers such as polysaccharides cannot be easily spun into fibres. In this study, we demonstrate the possibility of using polymer blends for the preparation of nanofibres that offer substantial mucoadhesive capabilities. Fibres from four different polymers were obtained by pressurised gyration at different working pressures and a rotation speed of 24,000 rpm. Electron microscopy indicates that structurally well-defined fibres with diameters from less than 100 nm upwards were successfully produced. Quantitative relationships between the physical properties and fibre characteristics were established while the fibre compositions were confirmed to contain features likely to confer mucoadhesive properties. Finally, a combination of texture analysis and atomic force microscopy was used to verify the benefit of transforming polymer powders into nanofibre structures, as far as mucoadhesive potential is concerned. (C) 2015 The Authors. Published by Elsevier Ltd.