Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV.
Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV.
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DOI：
10.1080/09540121.2014.920949
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发表时间：
2014
期刊：
影响因子：
1.7
通讯作者：
SEARCH 012 Study Team
中科院分区：
文献类型：
--
作者：
Kerr SJ;Puthanakit T;Vibol U;Aurpibul L;Vonthanak S;Kosalaraksa P;Kanjanavanit S;Hansudewechakul R;Wongsawat J;Luesomboon W;Ratanadilok K;Prasitsuebsai W;Pruksakaew K;van der Lugt J;Paul R;Ananworanich J;Valcour V;SEARCH 012 Study Team
Human immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared to age- and gender-matched controls whose lives have not been affected by HIV. This could occur due to exposure to HIV and antiretroviral agents in utero and perinatally, or differences in the environment in which they grow up. This study assessed neurodevelopmental outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children enrolled as controls in a multicenter ND study from Thailand and Cambodia. One hundred sixty HEU and 167 HUU children completed a neurodevelopmental assessment using the Beery Visual Motor Integration (VMI) test, Color Trails, Perdue Pegboard, and Child Behavior Checklist (CBCL). Thai children (n = 202) also completed the Wechsler Intelligence Scale (IQ) and Stanford-Binet II memory tests. In analyses adjusted for caregiver education, parent as caregiver, household income, age, and ethnicity, statistically significant lower scores were seen on verbal IQ (VIQ), full-scale IQ (FSIQ), and Binet Bead Memory among HEU compared to HUU. The mean (95% CI) differences were −6.13 (−10.3 to −1.96), p = 0.004; −4.57 (−8.80 to −0.35), p = 0.03; and −3.72 (−6.57 to −0.88), p = 0.01 for VIQ, FSIQ, and Binet Bead Memory, respectively. We observed no significant differences in performance IQ, other Binet memory domains, Color Trail, Perdue Pegboard, Beery VMI, or CBCL test scores. We conclude that HEU children evidence reductions in some neurodevelopmental outcomes compared to HUU; however, these differences are small and it remains unclear to what extent they have immediate and long-term clinical significance.
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影响因子：
56.3
作者：
Puthanakit, Thanyawee;Saphonn, Vonthanak;Ruxrungtham, Kiat
通讯作者：
Ruxrungtham, Kiat
影响因子：
1.7
作者：
Malee KM;Tassiopoulos K;Huo Y;Siberry G;Williams PL;Hazra R;Smith RA;Allison SM;Garvie PA;Kammerer B;Kapetanovic S;Nichols S;Van Dyke R;Seage GR 3rd;Mellins CA;Pediatric HIV/AIDS Cohort Study Team
通讯作者：
Pediatric HIV/AIDS Cohort Study Team
影响因子：
3.6
作者：
Mellins, Claude A.;Brackis-Cott, Elizabeth;Meyer-Bahlburg, Heino F. L.
通讯作者：
Meyer-Bahlburg, Heino F. L.
DOI：
10.1097/inf.0b013e31827fb19d
发表时间：
2013-05
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Puthanakit T;Ananworanich J;Vonthanak S;Kosalaraksa P;Hansudewechakul R;van der Lugt J;Kerr SJ;Kanjanavanit S;Ngampiyaskul C;Wongsawat J;Luesomboon W;Vibol U;Pruksakaew K;Suwarnlerk T;Apornpong T;Ratanadilok K;Paul R;Mofenson LM;Fox L;Valcour V;Brouwers P;Ruxrungtham K;PREDICT Study Group
通讯作者：
PREDICT Study Group
影响因子：
4.9
作者：
Mellins, Claude A.;Tassiopoulos, Katherine;Seage, George R., III
通讯作者：
Seage, George R., III