Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients
Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients
复制标题
补体5基因多态性与中国患者大动脉粥样硬化性卒中相关
DOI：
10.1590/0004-282x20160139
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Jing Zhao
中科院分区：
文献类型：
--
作者：
Hui Wu;Lan Zheng;Huanyin Li;Qi Gong;Yi Fu;Jing Zhao
摘要补体系统已被证实在缺血性卒中(IS)中发挥着越来越重要的作用。本研究旨在确定补体5(C5)基因单核苷酸多态性是否独立地影响中国患者IS的发生、严重程度和长期预后。方法对494例IS患者和330例正常对照进行C5rs17611基因变异分析，将缺血性卒中分为不同亚型，并在卒中后90d用改良Rankin量表对患者进行评估，以确定卒中结局。结果C5基因多态性与大动脉粥样硬化的发病相关(n=200；p=0.031)，在调整协变量后仍存在(OR=1.518；95%CI=1.093~2.018；p=0.013)。然而，未发现基因分型与中风的严重程度和预后之间存在关联(p=0.978；p=0.296)。结论C5基因多态性可能与LAA亚型的发病风险有关，且与其他已知的风险预测因素无关。
ABSTRACT The complement system has been confirmed to play an increasingly important role in ischemic stroke (IS). This study aimed to determine whether the single-nucleotide polymorphism of the complement 5 (C5) gene independently influences the occurrence, severity, and long-term outcome of IS in Chinese patients. Methods C5 rs17611 genetic variants were investigated in 494 IS patients and 330 control individuals .Ischemic stroke was classified into subtypes and patients were assessed 90 days post-stroke with the modified Rankin Scale to determine stroke outcome. Results The presence of C5 polymorphism was associated with the incidence of large artery atherosclerosis (LAA)-subtype IS (n =2 00; p = 0.031), which even persisted after adjustment for covariates (OR = 1.518; 95%CI = 1.093–2.018; p = 0.013). However, no association was found between genotypes and the severity and outcome of stroke (p = 0.978; p = 0.296). Conclusions The C5 polymorphism might contribute to the risk of LAA-subtype IS independently of other known risk predictors.
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DOI：
10.4049/jimmunol.1402956
发表时间：
2015-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Giles JL;Choy E;van den Berg C;Morgan BP;Harris CL
通讯作者：
Harris CL
影响因子：
15.9
作者：
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通讯作者：
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DOI：
10.1161/01.atv.9.6.802
发表时间：
1989-11-01
期刊：
ARTERIOSCLEROSIS
影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1365-2362.2012.02669.x
发表时间：
2012-09-01
影响因子：
5.5
作者：
Hoke, Matthias;Speidl, Walter;Mannhalter, Christine
通讯作者：
Mannhalter, Christine
DOI：
10.1016/s1474-4422(12)70234-x
发表时间：
2012-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Traylor M;Farrall M;Holliday EG;Sudlow C;Hopewell JC;Cheng YC;Fornage M;Ikram MA;Malik R;Bevan S;Thorsteinsdottir U;Nalls MA;Longstreth W;Wiggins KL;Yadav S;Parati EA;Destefano AL;Worrall BB;Kittner SJ;Khan MS;Reiner AP;Helgadottir A;Achterberg S;Fernandez-Cadenas I;Abboud S;Schmidt R;Walters M;Chen WM;Ringelstein EB;O'Donnell M;Ho WK;Pera J;Lemmens R;Norrving B;Higgins P;Benn M;Sale M;Kuhlenbäumer G;Doney AS;Vicente AM;Delavaran H;Algra A;Davies G;Oliveira SA;Palmer CN;Deary I;Schmidt H;Pandolfo M;Montaner J;Carty C;de Bakker PI;Kostulas K;Ferro JM;van Zuydam NR;Valdimarsson E;Nordestgaard BG;Lindgren A;Thijs V;Slowik A;Saleheen D;Paré G;Berger K;Thorleifsson G;Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2);Hofman A;Mosley TH;Mitchell BD;Furie K;Clarke R;Levi C;Seshadri S;Gschwendtner A;Boncoraglio GB;Sharma P;Bis JC;Gretarsdottir S;Psaty BM;Rothwell PM;Rosand J;Meschia JF;Stefansson K;Dichgans M;Markus HS;International Stroke Genetics Consortium
通讯作者：
International Stroke Genetics Consortium