3DμF - Interactive Design Environment for Continuous Flow Microfluidic Devices
3DμF - Interactive Design Environment for Continuous Flow Microfluidic Devices
复制标题
3DμF - 连续流微流体装置的交互式设计环境
作者：
R. Sanka;J. Lippai;Dinithi Samarasekera;Sarah Nemsick;D. Densmore
微流控芯片实验室（LoC）系统的设计是一项繁重的任务，需要流体动力学，机械设计起草和制造方面的专业技能。工程师在设计微流体设备的劳动密集型过程中面临着重大挑战，很少有专业工具可以帮助自动化该过程。典型的设计迭代需要工程师研究架构，手动绘制设备布局，优化制造工艺，并手动计算和编程操作微流体设备的阀序列。当工程师不仅要测试芯片的功能，而且还要优化它们以实现生物测定的稳健执行时，问题就复杂了。在本文中，我们提出了一个交互式的工具，用于设计连续流动的微流体装置。3DμF是第一个完全开源的交互式微流控系统设计器，可随时支持最先进的设计自动化算法。通过各种案例研究，我们展示了3DμF可用于复制文献中的设计，提供评估微流体设计复杂性的指标，并展示了3DμF如何作为一个平台，将微流体设备设计中使用的各种工程技术集成为标准设计工作流程的一部分。
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation algorithms. Through various case studies, we show 3DμF can be used to reproduce designs from literature, provide metrics for evaluating microfluidic design complexity and showcase how 3DμF is a platform for integrating a wide assortment of engineering techniques used in the design of microfluidic devices as a part of the standard design workflow.
影响因子：
17.3
作者：
Walsh DI 3rd;Kong DS;Murthy SK;Carr PA
通讯作者：
Carr PA
ParchMint：微流体基准套件
DOI：
10.1109/iiswc.2018.8573487
发表时间：
2018
期刊：
2018 IEEE International Symposium on Workload Characterization
影响因子：
--
作者：
Crites, Brian;Sanka, Radhakrishna;Lippai, Joshua;McDaniel, Jeffrey;Brisk, Philip;Densmore, Douglas
通讯作者：
Densmore, Douglas
微流控超大规模集成（mVLSI）芯片半自动化设计案例
DOI：
10.23919/date.2017.7927283
发表时间：
2017
期刊：
Design Automation and Test in Europe
影响因子：
--
作者：
McDaniel, Jeffrey;Grover, William H.;Brisk, Philip
通讯作者：
Brisk, Philip