Aryl Aldehydes as Traceless Dielectrophiles in Bifunctional Titanocene-Catalyzed Propargylic C-X Activations
Aryl Aldehydes as Traceless Dielectrophiles in Bifunctional Titanocene-Catalyzed Propargylic C-X Activations
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DOI：
10.1021/ol202401n
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发表时间：
2011-10-21
期刊：
影响因子：
5.2
通讯作者：
Ashfeld, Brandon L.
中科院分区：
文献类型：
--
作者：
Campos, Catherine A.;Gianino, Joseph B.;Ashfeld, Brandon L.
The titanocene-catalyzed construction of all-carbon substituted tertiary centers directly from aromatic aldehydes is described. The starting aldehyde behaves as a traceless functionality in the formation of multiple carbon-carbon bonds through consecutive carbon-heteroatom bond activations. The sequential addition of a metal acetylide and a second carbon nucleophile to the dielectrophilic aldehyde enables the construction of symmetrical and unsymmetrical 1,4-diynes in good yields.
