The role of trophoblast in the physiological change in decidual spiral arteries
The role of trophoblast in the physiological change in decidual spiral arteries
复制标题
DOI：
10.1093/humrep/14.8.2131
复制
发表时间：
1999-08-01
影响因子：
6.1
通讯作者：
King, A
中科院分区：
文献类型：
--
作者：
Kam, EPY;Gardner, L;King, A
妊娠期母体子宫螺旋动脉的重塑，即生理变化，对胎儿的正常生长发育至关重要。胎儿滋养层细胞在螺旋动脉的形成中所起的作用一直存在争议。为了解决这一争论，进行了来自妊娠早期的人类妊娠的植入部位的血管与不存在滋养层的子宫组织的组织学和免疫化学比较。结果表明，只有在滋养细胞存在的情况下，才能发生以中膜坏死和纤维素样物质沉积为特征的真正的生理变化。此外，还发现滋养层亚群在此过程中的作用不同。间质滋养层介导的动脉中膜破坏先于血管内滋养层替代内皮细胞。
The remodelling of the maternal uterine spiral arteries during pregnancy, known as physiological change, is critical for the normal growth and development of the fetus. Controversy has surrounded the part played by fetal trophoblast in the transformation of these spiral arteries. To address this debate, a histological and immunochemical comparison of blood vessels from the implantation sites of human pregnancies of early gestation with uterine tissue where trophoblast was absent was performed. Results showed that true physiological change, with the features of medial necrosis and deposition of fibrinoid material, only occurred in the presence of trophoblast. In addition, it was found that subpopulations of trophoblast contribute differently in the process. Interstitial trophoblast-mediated destruction of the arterial media precedes replacement of the endothelial cells by endovascular trophoblast.