Comparison of pulmonary thin section CT findings and serum KL-6 levels in patients with sarcoidosis
Comparison of pulmonary thin section CT findings and serum KL-6 levels in patients with sarcoidosis
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DOI：
10.1259/bjr/65287605
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发表时间：
2011-03-01
影响因子：
2.6
通讯作者：
Kumamoto, T.
中科院分区：
文献类型：
--
作者：
Honda, K.;Okada, F.;Kumamoto, T.
目的：本研究旨在比较血清 KL-6 水平正常或升高的结节病患者的薄层 CT 图像。方法：回顾性分析 2003 年 12 月至 2008 年 11 月期间接受胸部薄层 CT 检查和血清 KL-6 测量的 101 例结节病患者。研究组包括 75 名 KL-6 水平正常（152-499 U ml(-1)，平均 305.7 U ml(-1)）的结节病患者（23 名男性，52 名女性；年龄 19-82 岁，平均 54.1 岁）和 26 名 KL-6 水平升高的结节病患者（7 名男性，19 名女性；年龄 19-75 岁，平均 54.3 岁） （541-2940 U ml(-1)，平均802.4 U ml(-1)）。两名胸部放射科医生在不了解 KL-6 水平的情况下，回顾性地独立判读 CT 图像，了解实质异常、淋巴结肿大和胸腔积液。结果：结节病患者的 CT 表现主要包括淋巴结肿大（KL-6 水平正常的 70/75 和 KL-6 水平升高的 21/26），其次是结节（正常和升高的水平分别为 50 和 25）和支气管壁增厚（正常水平和升高水平分别为 25 和 21）。 KL-6 水平升高的患者比正常水平的患者更常见磨玻璃样混浊、结节、小叶间隔增厚、牵拉性支气管扩张、结构扭曲和支气管壁增厚（p
Objective: This study aimed to compare thin-section CT images from sarcoidosis patients who had either normal or elevated serum KL-6 levels.Methods: 101 patients with sarcoidosis who underwent thin-section CT examinations of the chest and serum KL-6 measurements between December 2003 and November 2008 were retrospectively identified. The study group comprised 75 sarcoidosis patients (23 male, 52 female; aged 19-82 years, mean 54.1 years) with normal KL-6 levels (152-499 U ml(-1), mean 305.7 U ml(-1)) and 26 sarcoidosis patients (7 male, 19 female; aged 19-75 years, mean 54.3 years) with elevated KL-6 levels (541-2940 U ml(-1), mean 802.4 U ml(-1)). Two chest radiologists, unaware of KL-6 levels, retrospectively and independently interpreted CT images for parenchymal abnormalities, enlarged lymph nodes and pleural effusion.Results: CT findings in sarcoidosis patients consisted mainly of lymph node enlargement (70/75 with normal KL-6 levels and 21/26 with elevated KL-6 levels), followed by nodules (50 and 25 with normal and elevated levels, respectively) and bronchial wall thickening (25 and 21 with normal and elevated levels, respectively). Ground-glass opacity, nodules, interlobular septal thickening, traction bronchiectasis, architectural distortion and bronchial wall thickening were significantly more frequent in patients with elevated KL-6 levels than those with normal levels (p