THE DISTRIBUTION OF THE PROJECTION FROM THE HIPPOCAMPAL-FORMATION TO THE NUCLEUS ACCUMBENS IN THE RAT - AN ANTEROGRADE-HORSERADISH AND RETROGRADE-HORSERADISH PEROXIDASE STUDY
THE DISTRIBUTION OF THE PROJECTION FROM THE HIPPOCAMPAL-FORMATION TO THE NUCLEUS ACCUMBENS IN THE RAT - AN ANTEROGRADE-HORSERADISH AND RETROGRADE-HORSERADISH PEROXIDASE STUDY
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DOI：
10.1016/0306-4522(82)90198-1
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
DOMESICK, VB
中科院分区：
文献类型：
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作者：
KELLEY, AE;DOMESICK, VB
研究了大鼠海马区向伏隔核投射的分布和组织。在第一个实验中，将辣根过氧化物酶注射到fornicis菌毛中。穹窿纤维的大量顺行标记，使伏隔海马投影能够被详细绘制。标记穹窿纤维分布于伏隔核的整个长度，未向前连合前肢外侧扩散，投射仅限于内侧伏隔核。末端标记在紧邻隔的伏隔尾部背内侧区域特别密集。用微电泳法将辣根过氧化物酶注射到伏隔核中，以证实顺行实验的结果。当沉积物定位于穹窿分布场时，在枕下、枕前以及海马区CAI中观察到逆行标记的细胞，程度较轻。当沉积物位于穹窿分布区外时，未注意到海马标记。讨论了投影的地形。从海马体到伏隔核的投影得到证实。使用一种相对新颖的顺行-辣根过氧化物酶技术，提供了一幅纤维标记的图片，代表了穹穹系统的整个起源领域。讨论了该通路的纹状体投射场与其他纹状体传入事件的关系，特别强调纹状体的边缘传入。讨论了纹状体中所谓的“海马区”的神经递质组成及其在边缘系统影响中枢运动机制方面的功能重要性。
The distribution and organization of the projection from the hippocampal formation to the nucleus accumbens in the rat was investigated. In the 1st experiments, horseradish peroxidase was injected into the fimbria fornicis. Massive anterograde labeling of fornix fibers resulted, enabling the hippocampo-accumbens projection to be charted in detail. Labeled fornix fibers were distributed to the entire length of the nuclues accumbens and did not spread lateral to the anterior limb of the anterior commissure, the projection was limited to the medial nucleus accumbens. Terminal labeling was particularly dense in a caudal dorsomedial sector of accumbens immediately adjacent to the septum. Horseradish peroxidase was microelectrophoretically injected into the nuclues accumbens, to confirm the findings from the anterograde experiments. When the deposit was localized within the fornix distribution field retrogradely-labeled cells were observed in the subiculum, prosubiculum and, to a lesser extent, in hippocampal field CAI. When the deposit was located outside the fornix distribution field, no hippocampal labeling was noted. The topography of the projection was discussed. A projection from the hippocampal formation to the nucleus accumbens was confirmed. The use of a relatively novel anterograde-horseradish peroxidase technique, provided a picture of fiber labeling representing the entire field of origin of the fornix system. The striatal projection field of this pathway is discussed in relation to other striatal afferents, with particular emphasis on limbic afferentiation of the striatum. The so-called ''hippocampal district'' of striatum was discussed with respect to its neurotransmitter composition, as well as its functional importance regarding limbic system influence on central motor mechanisms.