PROPOLIS ALLERGY .2. THE SENSITIZING PROPERTIES OF 1,1-DIMETHYLALLYL CAFFEIC ACID ESTER
PROPOLIS ALLERGY .2. THE SENSITIZING PROPERTIES OF 1,1-DIMETHYLALLYL CAFFEIC ACID ESTER
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DOI：
10.1111/j.1600-0536.1987.tb02700.x
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发表时间：
1987-09-01
影响因子：
5.5
通讯作者：
POST, B
中科院分区：
文献类型：
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作者：
HAUSEN, BM;WOLLENWEBER, E;POST, B
如前所述，在外用制剂和化妆品中使用蜂胶或蜂胶的人中，越来越多的过敏反应是由其引起的。蜂胶及其主要的接触性过敏原，1，1-二甲基烯丙基咖啡酸酯，命名为LB-1，在患者和豚鼠实验中显示出强烈的致敏特性。9名患者接受了该化合物的斑贴试验，其中8人反应强烈。对不同杨树样品和白杨芽提取物的化学分离表明，LB-1始终存在。白杨芽分泌物是蜜蜂分泌的主要来源，因此是LB-1的来源。与其他几位作者一致，警告指出，由于其强烈的致敏性，不应将其用于局部产品。
As shown in the preceding paper, propolis or bee-glue is the cause of an increasing number of allergic reactions in persons using it in external preparations and cosmetics. Propolis and its main contact allergen, 1,1-dimethylallyl caffeic acid ester, designated LB-1, show strong sensitizing properties in patients as well as in guinea pig experiments. 9 patients have been patch tested with this compound, 8 of whom reacted strongly. Chemical separation of different propolis samples and poplar bud extracts reveal that LB-1 is always present. Poplar bud secretion is the bee''s major source for propolis and hence the origin of LB-1. A warning is indicated, in agreement with several other authors, that propolis should not be used in topical products because of its strong sensitizing properties.