NEMA NU-4 Performance Evaluation of the IRIS PET/CT Preclinical Scanner
NEMA NU-4 Performance Evaluation of the IRIS PET/CT Preclinical Scanner
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DOI：
10.1109/trpms.2017.2707300
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发表时间：
2017-07-01
影响因子：
4.4
通讯作者：
Del Guerra, Alberto
中科院分区：
文献类型：
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作者：
Belcari, Nicola;Camarlinghi, Niccolo;Del Guerra, Alberto
根据美国电气制造商协会NU 4-2008标准对IRIS PET/CT的PET组件进行了性能评估研究。IRIS PET/CT是一种高分辨率集成系统，用于小动物的PET和CT成像。我们评估了PET系统的性能，进行了以下措施：空间分辨率，灵敏度，计数率的能力，和图像质量参数。此外，显示了体内实验的两个实例。在511 keV处，整个模块的平均能量分辨率为14%。对于视场中心的点源，250-750 keV能量窗口的最大绝对灵敏度为8.0 +/- 1.1%，350-750 keV能量窗口的最大绝对灵敏度为6.6 +/- 1.0%。在250 - 750 keV范围内，鼠样和鼠样幻影的散射率分别为15.6%和22.4%。使用图像质量模型测量恢复系数，图像均匀性为7%，结果良好。在动物实验中证实了IRIS PET的成像性能。使用IRIS PET/CT，可以导出不同感兴趣区域的时间活动曲线，时间帧持续时间低至5 s，从而可以导出示踪剂输入函数。
This paper presents the performance assessment study of the PET component of the IRIS PET/CT according to the National Electrical Manufacturers Association NU 4-2008 standard. The IRIS PET/CT is a high-resolution integrated system for PET and CT imaging of small animals. We evaluated the performance of the PET system, carrying out the following measures: spatial resolution, sensitivity, counting rate capabilities, and image quality parameters. Furthermore, two examples of in vivo experiments are shown. The average energy resolution for a whole module is 14% at 511 keV. The maximum absolute sensitivity for a point source at the center of the fieldof- view is 8.0 +/- 1.1% for 250-750 keV energy window and 6.6 +/- 1.0% for 350-750 keV. The scatter fraction for mouselike and rat-like phantoms are 15.6% (250-750 keV) and 22.4% (350-750 keV), respectively. Recovery coefficients were measured with the image-quality phantom, providing good results with an image uniformity of 7%. The imaging performance of the IRIS PET are confirmed in the animal experiments. With the IRIS PET/CT, it was possible to derive the time activity curve for various regions of interest with time frame duration down to 5 s, thus enabling the possibility to derive the tracer input function.