The basic mechanism for the electrical stimulation of the nervous system
The basic mechanism for the electrical stimulation of the nervous system
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DOI：
10.1016/s0306-4522(98)00330-3
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发表时间：
1999-03-01
期刊：
影响因子：
3.3
通讯作者：
Rattay, F
中科院分区：
文献类型：
--
作者：
Rattay, F
神经信号可以通过细胞外电极或磁线圈产生或阻断。人工激励的新结果是基于目标神经元及其等效电网络的室室模型，以及广义激活函数理论。分析表明：(1)在大多数情况下，人工兴奋的来源在轴突内，而激发体细胞要困难得多；（ii）在中枢神经系统内，正、负阈值电流基本上取决于神经元相对于外加电场的位置和方向；（iii）在若干情况下，正电流刺激更容易；（iv）应该有可能在不产生传播动作电位的情况下激发突触活动。此外，广义激活函数理论为理解神经活动的阻滞提供了线索。(c) 1998 ibro。Elsevier Science Ltd.出版。
Neural signals can be generated or blocked by extracellular electrodes or magnetic coils. New results about artificial excitation are based on a compartmental model of a target neuron and its equivalent electrical network, as well as on the theory of the generalized activating function.The analysis shows that: (i) in most cases, the origin of artificial excitation is within the axon and the soma is much more difficult to excite; (ii) within the central nervous system, positive and negative threshold currents essentially depend on the position and orientation of the neurons relative to the applied electric field; (iii) in several cases, stimulation with positive currents is easier; and (iv) it should be possible to excite synaptic activity without the generation of propagating action potentials. Furthermore, the theory of the generalized activating function gives hints to understanding the blockage of neural activity. (C) 1998 IBRO. Published by Elsevier Science Ltd.