Receptor activator of nuclear factor kappa-B ligand (RANKL)/RANK signaling promotes cancer-related inflammation through M2 macrophages
Receptor activator of nuclear factor kappa-B ligand (RANKL)/RANK signaling promotes cancer-related inflammation through M2 macrophages
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DOI：
10.1111/exd.12949
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发表时间：
2016-05-01
影响因子：
3.6
通讯作者：
Aiba, Setsuya
中科院分区：
文献类型：
--
作者：
Fujimura, Taku;Kambayashi, Yumi;Aiba, Setsuya
本文讨论了测定佩吉特细胞释放的sRANKL对活化的核因子κ（RANK）+M2巨噬细胞的单核细胞源性CD 163 + CD 2016 + Arg 1+受体的免疫调节作用的研究。它讨论了RANK+K M2巨噬细胞在携带配体RANKL的肿瘤中的作用。讨论的结果包括RANKL/M2巨噬细胞在RANKL+肿瘤中通过直接和间接途径促进肿瘤进展的潜力。
The article discusses the study that determined immunomodulatory effects of sRANKL released from Paget cells on monocyte-derived CD163+CD2016+Arg1+receptor of activated nuclear factor kappa (RANK)+M2 macrophages. It discusses RANK+K M2 macrophages' role in ligand RANKL-bearing tumors. Findings discussed include potential of RANKL/M2 macrophages promoting tumor progression in direct and indirect pathways in RANKL+tumors.