A preliminary study of the in vivo behaviour of an emulsion formulation of indocyanine green
A preliminary study of the in vivo behaviour of an emulsion formulation of indocyanine green
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DOI：
10.1007/s101030050008
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发表时间：
1998-01-01
影响因子：
2.1
通讯作者：
Maillols, H
中科院分区：
文献类型：
--
作者：
Devoisselle, JM;Soulié-Bégu, S;Maillols, H
吲哚菁绿（ICG；）是一种荧光染料，主要用作功能指示剂、荧光成像造影剂，最近还用作二极管激光光凝过程中的增强剂。在这项研究中，吲哚菁绿被掺入乳液中以增加其在血液中的停留时间。体外结果表明，吲哚菁绿吸收峰向较长波长（从 778 nm 至 794 nm）移动，接近激光诱导光凝过程中使用的近红外二极管激光器的峰值发射波长（805 nm）。与以水溶液形式施用的 ICG 的血浆清除率相比，血浆清除率较慢（在 15-60 分钟的时间间隔内）。当吲哚菁绿加入到该乳液中时，ICG 在 805 nm 处的吸收能力显示出两到三倍的增加。
Indocyanine green (ICG;) is a fluorescent dye largely used as functional indicator, fluorescent imaging contrast agent and recently as enhancer during diode laser photocoagulation. In this study, indocyanine green was incorporated in an emulsion to increase its residence time in blood. In vitro results to show that indocyanine green absorption peak is shifted towards longer wavelength (from 778 nm to 794 nm) close to the peak emission wavelength of the near infrared diode laser (805 nm) used during laser-induced photocoagulation. Plasmatic clearance is slower (in the 15-60 min time interval) compared to the plasmatic clearance of ICG administered as an aqueous solution. The absorbing capacity of ICG at 805 nm shows a two- to threefold increase when indocyanine green is incorporated in this emulsion.