Development of an intravenous membrane oxygenator: enhanced intravenous gas exchange through convective mixing of blood around hollow fiber membranes.
Development of an intravenous membrane oxygenator: enhanced intravenous gas exchange through convective mixing of blood around hollow fiber membranes.
复制标题
开发静脉膜氧合器：通过中空纤维膜周围血液的对流混合来增强静脉内气体交换。
DOI：
10.1111/j.1525-1594.1994.tb03327.x
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发表时间：
1994
影响因子：
2.4
通讯作者：
Borovetz,HS
中科院分区：
文献类型：
--
作者：
Hattler,BG;Reeder,GD;Sawzik,PJ;Lund,LW;Walters,FR;Shah,AS;Rawleigh,J;Goode,JS;Klain,M;Borovetz,HS
据报道，新型静脉膜氧合器 (IMO) 原型进行了体外测试。 IMO 的新设计由围绕中心定位的三部分气球排列的缠结中空纤维膜组成。与静态模式（气球关闭）相比，插入设备后，较短的气体流动路径和一致、可重复的纤维几何形状使得气球激活时的氧通量增加高达 800%。与气球关闭相比，新的 IMO 装置在气球打开时运行会导致二氧化碳通量增加 400%。在 250 毫米汞柱的真空压力下，通过 14 厘米长的中空纤维的气体流速高达 9. 5 升/分钟。静脉膜氧合器的气体交换效率可以通过强调以下设计特征来提高：短气体流动路径、一致且可重复的纤维几何形状，以及最重要的是，增强中空纤维膜周围血液对流混合的主动方法
In vitro testing of a new prototype intravenous membrane oxygenator (IMO) is reported. The new IMO design consists of matted hollow fiber membranes arranged around a centrally positioned tripartite balloon. Short gas flow paths and consistent, reproducible fiber geometry after insertion of the device result in an augmented oxygen flux of up to 800% with balloon activation compared with the static mode (balloon off). Operation of the new IMO device with the balloon on versus the balloon off results in a 400% increase in carbon dioxide flux. Gas flow rates of up to 9. 5 L/min through the 14–cm–long hollow fibers have been achieved with vacuum pressures of 250 mm Hg. Gas exchange efficiency for intravenous membrane oxygenators can be increased by emphasizing the following design features: short gas flow paths, consistent and reproducible fiber geometry, and most importantly, an active means of enhancing convective mixing of blood around the hollow fiber membranes