THE INFLUENZA HERALD WAVE
THE INFLUENZA HERALD WAVE
复制标题
DOI：
10.1093/oxfordjournals.aje.a113441
复制
发表时间：
1982-01-01
影响因子：
5
通讯作者：
SIX, HR
中科院分区：
文献类型：
--
作者：
GLEZEN, WP;COUCH, RB;SIX, HR
流感研究中心的社区监测系统连续三年（1976年至1979年）在一个流行期的后半段发现了一波流感病毒感染，预示着下一年的流行病毒。对先驱波的识别需要对占人口相当大比例>2倍的人中发生的呼吸道疾病进行一致和连续的采样。 [美国]德克萨斯州哈里斯县有 106 人。在病毒检测的 2500-3000 种呼吸道疾病中，先驱波感染仅占 0.4-2.0%。在前两个流行时期，先驱波很容易被检测为甲型流感病毒流行期间发生的乙型流感病毒感染波，然后是乙型流感病毒流行期间发生的甲型流感病毒感染波。第三波先驱波之所以被掩盖，是因为它由少量由抗原性病毒引起的感染组成，例如在 A/USSR/90/77 (H1N1) 流感爆发结束时发生的 A/Brazil/11/78 (H1N1) 病毒。先驱波感染是在居住在该县广泛分散地区的人中发现的，这些人代表了所有年龄和社会经济群体。先驱波现象的明显好处是提供有关最有可能在下一个呼吸道疾病季节引发流行的病毒的信息。在最佳条件下，这可能需要 6-9 个月。制定和实施控制措施。
For 3 successive years (1976-1979), the community surveillance system of the Influenza Research Center identified a wave of influenza virus infections which occurred during the latter half of 1 epidemic period and which heralded the epidemic virus for the following year. Recognition of the herald waves required consistent and continuous sampling of respiratory illnesses occurring among persons who constituted a substantial proportion of the population of > 2 .times. 106 people in Harris County, Texas [USA]. The herald wave infections consisted of only 0.4-2.0% of the 2500-3000 respiratory illnesses examined for virus. During the first 2 epidemic peiods, the herald wave was easily detected as a wave of influenza B virus infections occurring during an influenza A virus epidemic and then a wave of influenza A virus infections during an influenza B virus epidemic. The 3rd herald wave was obscured because it consisted of a small number of infections caused by viruses antigenically like A/Brazil/11/78 (H1N1) which occurred at the end of the outbreak caused by influenza A/USSR/90/77 (H1N1). The herald wave infections were detected among persons who lived in widely scattered areas of the county and who were representative of all age and socioeconomic groups. The herald wave phenomenon has the obvious benefit of providing information about the virus most likely to produce an epidemic during the next respiratory disease season. Under optimal conditions, this could allow 6-9 mo. to prepare and administer control measures.