Vascular signaling through G protein-coupled receptors: new concepts.
Vascular signaling through G protein-coupled receptors: new concepts.
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通过 G 蛋白偶联受体的血管信号传导：新概念。
DOI：
10.1097/mnh.0b013e3283252efe
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发表时间：
2009
影响因子：
3.2
通讯作者：
Ushio-Fukai,Masuko
中科院分区：
文献类型：
--
作者：
Ushio-Fukai,Masuko
NADPH氧化酶衍生的ROS和NOS衍生的SNO现在被认为是调节GPCR信号传导的重要第二信使，从而有助于各种生物学和病理生理学功能。了解 ROS、一氧化氮和 SNO 如何调节 GPCR 信号传导的分子机制对于开发新的治疗方法至关重要。
NADPH oxidase-derived ROS and NOS-derived SNOs are now recognized as important second messengers to regulate GPCR signaling, thereby contributing to various biological and pathophysiological functions. Understanding the molecular mechanism of how ROS, nitric oxide, and SNOs might modulate GPCR signaling is essential for development of novel therapeutic approaches.