Effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels and skeletal muscle-fiber properties in diabetic rats
Effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels and skeletal muscle-fiber properties in diabetic rats
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DOI：
10.1002/mus.20692
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发表时间：
2007-03-01
期刊：
影响因子：
3.4
通讯作者：
Ishihara, Akihiko
中科院分区：
文献类型：
--
作者：
Yasuda, Koichiro;Adachi, Tetsuya;Ishihara, Akihiko
研究了高氧高压暴露对2型糖尿病Goto-Kakizaki大鼠血糖和胰岛素水平以及骨骼肌纤维特性的影响。将5周龄大鼠暴露于高氧浓度（36%）的高压环境（1.25个大气压）中，每天6小时。高压暴露4周后，检查比目鱼肌中的葡萄糖和胰岛素水平和特性，包括纤维类型分布、横截面积和氧化酶活性。生长相关的葡萄糖水平的增加被抑制高压暴露，胰岛素也显示出较低的水平与对照组相比。低氧化型I型纤维在肌肉中的百分比下降和高氧化型IIA和IIC型纤维，这是没有检测到在对照组大鼠的肌肉，观察高压暴露后。高压暴露后，肌肉中I型纤维的氧化酶活性增加。因此，高氧高压暴露可能为改善糖尿病引起的糖耐量、胰岛素抵抗和骨骼肌代谢改变提供了一种新的途径。
The effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels and skeletal muscle-fiber properties were investigated in type 2 diabetic Goto-Kakizaki rats. Five-week-old rats were exposed to a hyperbaric environment (1.25 atmospheric pressure) with a high oxygen concentration (36%) for 6 h daily. Glucose and insulin levels and properties including fiber-type distribution, cross-sectional area, and oxidative enzyme activity in the soleus muscle were examined after hyperbaric exposure for 4 weeks. The growth-related increase in glucose level was inhibited by hyperbaric exposure, and insulin also showed lower levels compared with control rats. The percentage of low-oxidative type I fibers in the muscle decreased and high-oxidative type IIA and type IIC fibers, which were not detected in the muscle of control rats, were observed after hyperbaric exposure. The oxidative enzyme activity of type I fibers in the muscle increased after hyperbaric exposure. Hyperbaric exposure with high oxygen concentration might therefore provide a new approach to improve the glucose tolerance, insulin resistance, and altered skeletal muscle metabolism that are caused by diabetes mellitus.