Sampling rare switching events in biochemical networks
Sampling rare switching events in biochemical networks
复制标题
DOI：
10.1103/physrevlett.94.018104
复制
发表时间：
2005-01-14
影响因子：
8.6
通讯作者：
ten Wolde, PR
中科院分区：
文献类型：
--
作者：
Allen, RJ;Warren, PB;ten Wolde, PR
双稳态生化开关广泛存在于基因调控网络和信号转导通路中。然而，它们的转换动力学很难研究，因为转换事件很少，而且系统处于不平衡状态。我们提出了一种模拟方法来预测这些开关的翻转速率和机制。我们将其应用于基因开关，发现它非常有效。正向和反向过程的路径集合不重合。该方法广泛适用于稀有事件和非平衡过程。
Bistable biochemical switches are widely found in gene regulatory networks and signal transduction pathways. Their switching dynamics are difficult to study, however, because switching events are rare, and the systems are out of equilibrium. We present a simulation method for predicting the rate and mechanism of the flipping of these switches. We apply it to a genetic switch and find that it is highly efficient. The path ensembles for the forward and reverse processes do not coincide. The method is widely applicable to rare events and nonequilibrium processes.