Congenital Deafness and Recent Advances Towards Restoring Hearing Loss.
Congenital Deafness and Recent Advances Towards Restoring Hearing Loss.
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DOI：
10.1002/cpz1.76
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Basch ML
中科院分区：
文献类型：
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作者：
Renauld JM;Basch ML
先天性听力损失是最常见的出生缺陷，估计每 1000 名新生儿中就有 2-3 人患有先天性听力损失。目前尚无治愈听力损失的方法。治疗选择仅限于针对轻度和中度听力损失的助听器，以及针对重度和极重度听力损失的人工耳蜗。在这里，我们提供了先天性听力损失的环境和遗传原因、用于听力研究的常见动物模型和方法以及开发治疗先天性耳聋疗法的最新进展的文献概述。 © 2021 作者。
Congenital hearing loss is the most common birth defect, estimated to affect 2‐3 in every 1000 births. Currently there is no cure for hearing loss. Treatment options are limited to hearing aids for mild and moderate cases, and cochlear implants for severe and profound hearing loss. Here we provide a literature overview of the environmental and genetic causes of congenital hearing loss, common animal models and methods used for hearing research, as well as recent advances towards developing therapies to treat congenital deafness. © 2021 The Authors.