Intensive care unit management of patients with status epilepticus
Intensive care unit management of patients with status epilepticus
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DOI：
10.1111/j.1528-1167.2007.01352.x
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发表时间：
2007-01-01
期刊：
影响因子：
5.6
通讯作者：
Bleck, Thomas P.
中科院分区：
文献类型：
--
作者：
Bleck, Thomas P.
癫痫持续状态的重症监护病房管理的重点是那些对最初的治疗难以接受的患者，他们有需要重症护理的潜在疾病，或者他们在治疗中经历了呼吸系统或心血管并发症。现有的数据表明，一线抗惊厥药物终止状态的失败应导致使用全麻剂剂量的明确治疗。咪达唑仑、异丙酚和苯巴比妥的使用频率最高；新的药物(如丙戊酸盐、左乙拉西坦或托吡酯)的位置仍有待确定。
The intensive care unit management of status epilepticus focuses on patients who are refractory to initial treatment, who have an underlying condition that require critical care management, or who experience respiratory or cardiovascular complications of their therapies. The available data suggest that failure of a first-line anticonvulsant agent to terminate status should lead to the use of a definitive therapy in general anesthetic doses. Midazolam, propofol, and phenobarbital have been used most frequently; the place of newer agents (e.g., valproate, levetiracetam, or topiramate) remains to be determined.